A6TV07 (KATG2_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase-peroxidase 2
Short name=CP 2
EC=1.11.1.21

Alternative name(s):
Peroxidase/catalase 2

Gene names

Name:	katG2
Ordered Locus Names:	Amet_3934

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 2 H2O2 = O2 + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Caution	Could be the product of a pseudogene. The N-terminus is much shorter than in related proteins and lacks the active sites and the heme-binding sites. Moreover, the 71 first amino acids of this sequence are not homologous to other katG sequences.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Domain	Signal
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 416	396	Catalase-peroxidase 2 HAMAP MF_01961		PRO_0000354719

Sequences

	Sequence		Length	Mass (Da)
	A6TV07 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 01ACF81E6638AD38	FASTA	416	46,834
	10 20 30 40 50 60 MLLPLIVFLL SVLIHHRIYS SFFLHFYSPQ YYMICSRLTL LSSCSWHDFH LKLILLEFAS 70 80 90 100 110 120 QSTNPVPALH NDPTYEKISR RFHENPEAFA DVFARAWFKL LHRDMGPQTR YLGPEVPEEE 130 140 150 160 170 180 LIWQDPIPAV DYELTDAEIA ELKAKILDSG LTVSDLVTTA WASASTFRGS DMRGGANGAR 190 200 210 220 230 240 IRLAPQKDWE VNQPEQLTKV LTVLEDIQNQ LDKKVSIADL IVLGGSAAIE KSAQDAGFDV 250 260 270 280 290 300 TVPFALGRGD ATQEQTDIES FEVLEPISDG FRNYQKKQYS VSAEELLLDK AQLLNLTAPE 310 320 330 340 350 360 MTVLVDGMRV LGTNYNGTQH GVFTDRVGTL TNDFFVNLLD MGVEWKPMDG GLYEARNRKT 370 380 390 400 410 GEVVRTATRV DLVFGSNSVL RALVEVYAQD DNKEKFVGDF IAAWIKVMNA DRFDLD

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR50025.1.
RefSeq	YP_001321684.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TV07.
SMR	A6TV07. Positions 68-415.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TV07.
Protein family/group databases
PeroxiBase	3625. AmeCP02_QYMF.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5314015.
GenomeReviews	Gene locus Amet_3934 in contig CP000724_GR.
KEGG	amt:Amet_3934.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0376.
OMA	HHRIYSS.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_3934-MONOMER.
Family and domain databases
HAMAP	MF_01961. Catal-peroxid. Divergent sequence. [Tree]
InterPro	IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. False negative. PS50873. PEROXIDASE_4. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG2_ALKMQ

Accession

Primary (citable) accession number: A6TV07

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program