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Protein

Xylose isomerase

Gene

xylA

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001UniRule annotation
Active sitei103 – 1031UniRule annotation
Metal bindingi231 – 2311Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 2UniRule annotation
Metal bindingi270 – 2701Magnesium 2UniRule annotation
Metal bindingi295 – 2951Magnesium 1UniRule annotation
Metal bindingi306 – 3061Magnesium 2UniRule annotation
Metal bindingi308 – 3081Magnesium 2UniRule annotation
Metal bindingi338 – 3381Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAMET293826:GI5P-3850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Amet_3796Imported
OrganismiAlkaliphilus metalliredigens (strain QYMF)Imported
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000001572 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi293826.Amet_3796.

Structurei

3D structure databases

ProteinModelPortaliA6TUP7.
SMRiA6TUP7. Positions 3-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TUP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREHFLEINK IKFEGGDSTN PLAFKYYDAN RIVAGKKMKD HLRFALSYWH
60 70 80 90 100
TLTGNGTDPF GQPTMERDYN SLDGIELSKA RVDAAFELMT KLGIEFFCFH
110 120 130 140 150
DLDIAPEGNS LQEKLDNLDT ILERIEDKMK ETGIKCLWGT TNAFSHPRFM
160 170 180 190 200
HGAATSPNAD VFAFAAAQVK KALEITHRLR GENYVFWGGR EGYETLLNTD
210 220 230 240 250
IALENDNLAK FLKMAKDYAR NIGFEGQFLI EPKPKEPTKH QYDFDTMTVL
260 270 280 290 300
GFLRKYNLID DFKLNIEANH ATLAGHTFQH ELAMARINGV LGSVDANQGD
310 320 330 340 350
LLLGWDTDQF PTNIYDATLS MYEVLKNGGI APGGLNFDAK VRRGSFKPDD
360 370 380 390 400
LFIAYIVGMD TFAKGLLVAD KLLTDGVLEN FVTKRYESYT AGIGKKIIED
410 420 430
ATSFEELAEY ALKHDKIVLE SGRQEMLEDI VNRYIYK
Length:437
Mass (Da):49,449
Last modified:August 21, 2007 - v1
Checksum:iEF052ED533C62143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA. Translation: ABR49915.1.
RefSeqiWP_012064875.1. NC_009633.1.
YP_001321574.1. NC_009633.1.

Genome annotation databases

EnsemblBacteriaiABR49915; ABR49915; Amet_3796.
KEGGiamt:Amet_3796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA. Translation: ABR49915.1.
RefSeqiWP_012064875.1. NC_009633.1.
YP_001321574.1. NC_009633.1.

3D structure databases

ProteinModelPortaliA6TUP7.
SMRiA6TUP7. Positions 3-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi293826.Amet_3796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR49915; ABR49915; Amet_3796.
KEGGiamt:Amet_3796.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciAMET293826:GI5P-3850-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Alkaliphilus metalliredigens QYMF."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QYMFImported.

Entry informationi

Entry nameiA6TUP7_ALKMQ
AccessioniPrimary (citable) accession number: A6TUP7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 27, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.