Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6TUG2 (A6TUG2_ALKMQ) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Amet_3710 EMBL ABR49830.1
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP] EMBL ABR49830.1
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain135 – 341207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding168 – 22356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2941Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3071Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3071Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3091Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
A6TUG2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 9FF658FBCC283A2B

FASTA35840,747
        10         20         30         40         50         60 
MKTNVYVLCG GKSVEHRVSL ISASAIINSL DKKKYHVYPI YISDEGIWSN LGIVEDEIKE 

        70         80         90        100        110        120 
ISELMYQSSN TVISSIETFL RSSFNEREQN IVFPALHGTN GEDGTIQGLL EILDIPYVGN 

       130        140        150        160        170        180 
GVMSSAIGID KVVTKDLFAK HNIPQGKYTR LLQHQWKKDK LFSIERIEET IGYPAYVKPA 

       190        200        210        220        230        240 
SLGSSVGINR CANREELEAA IHEAFSFEDK LVIEEEIIGR EMQISVVGNE FPKASVVGEF 

       250        260        270        280        290        300 
IQERQFMDYA AKYTDGKLIQ VIPAKLTEKV SELMREVAIK SFDVLNCSGL VRVDYFVTDD 

       310        320        330        340        350 
ERFYVNEVNT MPGFTKLSMT PALWEKTDQT TYPELIEKLI NLAFERYNKR KSFLYKRK 

« Hide

References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000724 Genomic DNA. Translation: ABR49830.1.
RefSeqYP_001321489.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TUG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING293826.Amet_3710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR49830; ABR49830; Amet_3710.
GeneID5313791.
KEGGamt:Amet_3710.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAWREAARY.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycAMET293826:GI5P-3764-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6TUG2_ALKMQ
AccessionPrimary (citable) accession number: A6TUG2
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)