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A6TUE9 (MSRA_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA

Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase
Gene names
Name:msrA
Ordered Locus Names:Amet_3697
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 158158Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
PRO_1000068306

Sites

Active site101 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6TUE9 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 64DE90677DEE810D

FASTA15818,111
        10         20         30         40         50         60 
MKEIVLAGGC FWGVEAYMER IDGVVETKVG YANGHVENPS YEEVCSSQTG HAEVCYIKFD 

        70         80         90        100        110        120 
ETKISLEILL NGFWKIIDPT VENRQGPDIG SQYRTGIYYG HEEDLDTIIK SKEMQQKKYD 

       130        140        150 
ANIVTEIEPL KAFYDAEEYH QKYLKKNPGG YCHINLEI 

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References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000724 Genomic DNA. Translation: ABR49817.1.
RefSeqYP_001321476.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TUE9.
SMRA6TUE9. Positions 1-157.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TUE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5313778.
GenomeReviewsGene locus Amet_3697 in contig CP000724_GR.
KEGGamt:Amet_3697.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
HOGENOMHBG748152.
OMAERKIMTE.
ProtClustDBPRK14054.

Enzyme and pathway databases

BioCycAMET293826:AMET_3697-MONOMER.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_ALKMQ
AccessionPrimary (citable) accession number: A6TUE9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families