A6TTJ3 (ARGC_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Amet_3383

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000058152
Sites
	Active site	150	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6TTJ3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4C4DBF537C84D069	FASTA	346	38,255
	10 20 30 40 50 60 MIKAGILGST GYAGAELVRL LTGHPEVEIQ FLDSRSYHGK AYEEVYPSLK NIVKGKCASI 70 80 90 100 110 120 DLENDFEGID ILFCALPHGL SQEAVKRMMA KGKRVIDLSA DFRITDPKVY EAWYDVRHQA 130 140 150 160 170 180 LGELGKAVYG LSEIYPKEIQ EAQLVANPGC YPTSIALALY PLLKENVIST ESIIIDAKSG 190 200 210 220 230 240 VSGAGRNLND GTLFSQCNEN IKAYSIGTHR HIPEIEQELS LAAGKEMIIQ FTPHLVPMNR 250 260 270 280 290 300 GILSTIYTTN IKNVKENDIE AIYAHYYEEK RFVRLLKEGK LPQTKAVSGS NYCDIGFKVD 310 320 330 340 PRTNGLIVVS AIDNLVKGAA GQAVQNMNMM LGLKEYIGLE QMPIWP

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR49511.1.
RefSeq	YP_001321170.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TTJ3.
SMR	A6TTJ3. Positions 1-346.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TTJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5313463.
GenomeReviews	Gene locus Amet_3383 in contig CP000724_GR.
KEGG	amt:Amet_3383.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_3383-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ALKMQ

Accession

Primary (citable) accession number: A6TTJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program