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A6TSW9 (HUTI_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazolonepropionase
EC=3.5.2.7
Alternative name(s):
Imidazolone-5-propionate hydrolase
Gene names
Name:hutI
Ordered Locus Names:Amet_3148
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372

Cofactor

Binds 1 zinc or iron ion per subunit By similarity. HAMAP MF_00372

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372

Subcellular location

Cytoplasm Potential HAMAP MF_00372.

Sequence similarities

Belongs to the HutI family.

Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionimidazolonepropionase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Imidazolonepropionase HAMAP MF_00372
PRO_1000059941

Sites

Metal binding821Zinc or iron By similarity
Metal binding841Zinc or iron By similarity
Metal binding2521Zinc or iron By similarity
Metal binding3271Zinc or iron By similarity
Binding site911Substrate By similarity
Binding site1041Substrate By similarity
Binding site1541Substrate By similarity
Binding site1871Substrate By similarity
Binding site2551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A6TSW9 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1E6B2F84BC83760E

FASTA42245,831
        10         20         30         40         50         60 
MMVDVLIKDI SQMVTMKGSN GPRRGKDMRE VHLIEDGWIA IKGDKIVAVG SGLMEENLKI 

        70         80         90        100        110        120 
GKNTMVIDGK GKTVTPGLVD PHTHLVHGGS RENELALKLN GVPYLDILAQ GGGILSTVKA 

       130        140        150        160        170        180 
TRKATVEELM QQGKRSLDQM LSFGVTTVEV KSGYGLNTET ELKQLEVIRQ LNKEHPCDLV 

       190        200        210        220        230        240 
PTFMGAHAIP MEYKEDPDVF VDIVIDEMLP AVVERGLAEF CDVFCEKGVF TVAQSRRVLE 

       250        260        270        280        290        300 
AAREAGLKLR IHVDEIEALG GAELAAEMGA ITAEHLMVTS EEDMKKMAKA GVIAALLPGT 

       310        320        330        340        350        360 
SFNLMVGKYA QARKMIDYGV PITLSTDYNP GSCPTENIQF IMTLGCLAMK MTPEEVFTAV 

       370        380        390        400        410        420 
TINGAAAVDR QGDIGSLEVG KKADVVIFNA PNINYIPYHF GINHVDKVLK NGKLVVDKGR 


VI

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References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000724 Genomic DNA. Translation: ABR49287.1.
RefSeqYP_001320946.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TSW9.
SMRA6TSW9. Positions 5-418.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TSW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5313225.
GenomeReviewsGene locus Amet_3148 in contig CP000724_GR.
KEGGamt:Amet_3148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1228.
HOGENOMHBG686142.
OMAMNMACTL.
ProtClustDBPRK09356.

Enzyme and pathway databases

BioCycAMET293826:AMET_3148-MONOMER.

Family and domain databases

HAMAPMF_00372. HutI.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01468.
PANTHERPTHR22642. PTHR22642. 1 hit.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01224. HutI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHUTI_ALKMQ
AccessionPrimary (citable) accession number: A6TSW9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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