Reviewed, UniProtKB/Swiss-Prot A6TRU6 (ACKA_ALKMQ)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	Amet_2763

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Acetate kinase HAMAP MF_00020		PRO_1000057184

Sequences

	Sequence		Length	Mass (Da)
	A6TRU6-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2871B19A5F773285	FASTA	396	43,252
	10 20 30 40 50 60 MKILVMNCGS SSLKYQLINM ENEEVLAIGL AERIGIAGAR VKHEASGKEK VTIEQPMENH 70 80 90 100 110 120 KTAIKIVLEA LIDENYGAIK SMDEIAAVGH RVVHGGERFS SSVVVTDDVK NALEECSDLA 130 140 150 160 170 180 PLHNPPNLMG IEACQEILPN VPMVGVFDTA FHQTMPESSY MYALPYELYE KHKIRRYGFH 190 200 210 220 230 240 GTSHKYVAMK AAEILERPIE DLKIIACHLG NGASITAVDG GISVDTSMGF TPLEGLVMGT 250 260 270 280 290 300 RCGDMDPAIV TFLMEKEKID HNQVNAIMNK QSGVYGLSGV SSDFRDIEVA VKEGNKRAQL 310 320 330 340 350 360 ALDVYYKRVK KYIGAYAAEM GGVDAVVFTA GLGENSPETR KSICEGLEFL GIKIDNTKNN 370 380 390 VRGKETVVST DDTPTKVLLI PTNEELAIAR ETKSLI

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR48914.1.
RefSeq	YP_001320573.1.
3D structure databases
SMR	A6TRU6. Positions 1-396.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TRU6.
Genome annotation databases
GeneID	5312835.
GenomeReviews	Gene locus Amet_2763 in contig CP000724_GR.
KEGG	amt:Amet_2763.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	IVTFLME.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_ALKMQ

Accession

Primary (citable) accession number: A6TRU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)