A6TQN8 (APT_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	Amet_2352

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_1000057027

Sequences

	Sequence		Length	Mass (Da)
	A6TQN8 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: ADC9DFB5E7795832	FASTA	170	18,488
	10 20 30 40 50 60 MNLDSKIRVI EDFPKKGISF KDITTLLKDK EAFRSMVDQL SDQLIDLDID IVVGPEARGF 70 80 90 100 110 120 LVGAPVAYKI GAGFVPIRKP GKLPGETISY EYELEYGTDS LEIHTDAIQP GQRVAILDDL 130 140 150 160 170 LATGGTVVAT AKLIEELGGE VVSINFLIEL GFLNGGEVLK GYSVKSLLKY

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR48506.1.
RefSeq	YP_001320165.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TQN8.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TQN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5312424.
GenomeReviews	Gene locus Amet_2352 in contig CP000724_GR.
KEGG	amt:Amet_2352.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HBG703830.
OMA	GMEARGF.
ProtClustDB	PRK02304.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_2352-MONOMER.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. Apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_ALKMQ

Accession

Primary (citable) accession number: A6TQN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program