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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei583ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMET293826:G1G94-2333-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Amet_2314
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000001572 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000912851 – 824Leucine--tRNA ligaseAdd BLAST824

Proteomic databases

PRIDEiA6TQK3

Interactioni

Protein-protein interaction databases

STRINGi293826.Amet_2314

Structurei

3D structure databases

ProteinModelPortaliA6TQK3
SMRiA6TQK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionAdd BLAST11
Motifi580 – 584"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6TQK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIYDFGNIE KKWQERWQEN KAFSIIERDR PKYYVLEMFP YPSGKIHMGH
60 70 80 90 100
VRNYSIGDVV ARFKRMKGYN VLHPMGWDSF GLPAENAAIK HGIHPDHWTK
110 120 130 140 150
ENVKEMKEQL DALGLSYDWD REVSTCTPEY YKWTQWLFLQ FYHKGLAYKK
160 170 180 190 200
ESQVNWCPSC ETVLANEQVV NGGCDRCDSS VGKKNLNQWY FKITDYAEAL
210 220 230 240 250
LEDIKLLDGW PEKVKTMQQN WIGKSHGAEI DFPIENTSKE LKVFTTRPDT
260 270 280 290 300
IYGATYMVLA PEHPYVMELV KETEYEEAVV AFRNKLQHMS DIERTSTEIE
310 320 330 340 350
KEGIFIGKYC INPVSNEKIP IYIANYVLAD YGTGAIMAVP AHDQRDLDFA
360 370 380 390 400
RKYDITVTPV IRPIDESDGF DIEKEAYTDS GIMINSEKFN GLDSEKAYED
410 420 430 440 450
IAKHIETLNA GKRTINYRLR DWLLSRQRYW GTPIPIIYCD DCGIVPVREE
460 470 480 490 500
ELPVKLPVDV TFSGKGSSPL ETSEGFLNTN CPSCGKMAKR ETDTMDTFVD
510 520 530 540 550
SSWYFLRYTD ANNEQLPFSK EAANYWVPVD QYIGGVEHAI LHLLYSRFFT
560 570 580 590 600
KVMKDLGLTD QPEPFKKLLT QGMVLKDGAK MSKSKGNVVS PEEIIQKYGA
610 620 630 640 650
DTARLFVLFA APPERDLEWS DQGVEGSYRF LNRVWRLAEE FIDNNLFMST
660 670 680 690 700
SLGEALTKRD KDLKYTIHYT IKKVTSDVED RFNFNTAISA VMELINELYK
710 720 730 740 750
YKETDPSKLN GDLFREGIET SILLLAPFAP HFTEELWEKL GKAESVHMTN
760 770 780 790 800
WPEYDHEAII KDEVEIVMQV NGKVKDRMMV PTNVSKEELE SLAMKNEKII
810 820
QIIEGKQIIK IIAVPKKLVN IVIK
Length:824
Mass (Da):95,056
Last modified:August 21, 2007 - v1
Checksum:i7CAF3459E6CB80F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA Translation: ABR48471.1
RefSeqiWP_012063446.1, NC_009633.1

Genome annotation databases

EnsemblBacteriaiABR48471; ABR48471; Amet_2314
KEGGiamt:Amet_2314

Similar proteinsi

Entry informationi

Entry nameiSYL_ALKMQ
AccessioniPrimary (citable) accession number: A6TQK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome