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A6TQK3

- SYL_ALKMQ

UniProt

A6TQK3 - SYL_ALKMQ

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Protein

Leucine--tRNA ligase

Gene
leuS, Amet_2314
Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMET293826:GI5P-2358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Amet_2314
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000001572: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligaseUniRule annotationPRO_1000091285Add
BLAST

Proteomic databases

PRIDEiA6TQK3.

Interactioni

Protein-protein interaction databases

STRINGi293826.Amet_2314.

Structurei

3D structure databases

ProteinModelPortaliA6TQK3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotationAdd
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TQK3-1 [UniParc]FASTAAdd to Basket

« Hide

MAIYDFGNIE KKWQERWQEN KAFSIIERDR PKYYVLEMFP YPSGKIHMGH    50
VRNYSIGDVV ARFKRMKGYN VLHPMGWDSF GLPAENAAIK HGIHPDHWTK 100
ENVKEMKEQL DALGLSYDWD REVSTCTPEY YKWTQWLFLQ FYHKGLAYKK 150
ESQVNWCPSC ETVLANEQVV NGGCDRCDSS VGKKNLNQWY FKITDYAEAL 200
LEDIKLLDGW PEKVKTMQQN WIGKSHGAEI DFPIENTSKE LKVFTTRPDT 250
IYGATYMVLA PEHPYVMELV KETEYEEAVV AFRNKLQHMS DIERTSTEIE 300
KEGIFIGKYC INPVSNEKIP IYIANYVLAD YGTGAIMAVP AHDQRDLDFA 350
RKYDITVTPV IRPIDESDGF DIEKEAYTDS GIMINSEKFN GLDSEKAYED 400
IAKHIETLNA GKRTINYRLR DWLLSRQRYW GTPIPIIYCD DCGIVPVREE 450
ELPVKLPVDV TFSGKGSSPL ETSEGFLNTN CPSCGKMAKR ETDTMDTFVD 500
SSWYFLRYTD ANNEQLPFSK EAANYWVPVD QYIGGVEHAI LHLLYSRFFT 550
KVMKDLGLTD QPEPFKKLLT QGMVLKDGAK MSKSKGNVVS PEEIIQKYGA 600
DTARLFVLFA APPERDLEWS DQGVEGSYRF LNRVWRLAEE FIDNNLFMST 650
SLGEALTKRD KDLKYTIHYT IKKVTSDVED RFNFNTAISA VMELINELYK 700
YKETDPSKLN GDLFREGIET SILLLAPFAP HFTEELWEKL GKAESVHMTN 750
WPEYDHEAII KDEVEIVMQV NGKVKDRMMV PTNVSKEELE SLAMKNEKII 800
QIIEGKQIIK IIAVPKKLVN IVIK 824
Length:824
Mass (Da):95,056
Last modified:August 21, 2007 - v1
Checksum:i7CAF3459E6CB80F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000724 Genomic DNA. Translation: ABR48471.1.
RefSeqiWP_012063446.1. NC_009633.1.
YP_001320130.1. NC_009633.1.

Genome annotation databases

EnsemblBacteriaiABR48471; ABR48471; Amet_2314.
GeneIDi5312385.
KEGGiamt:Amet_2314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000724 Genomic DNA. Translation: ABR48471.1 .
RefSeqi WP_012063446.1. NC_009633.1.
YP_001320130.1. NC_009633.1.

3D structure databases

ProteinModelPortali A6TQK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293826.Amet_2314.

Proteomic databases

PRIDEi A6TQK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR48471 ; ABR48471 ; Amet_2314 .
GeneIDi 5312385.
KEGGi amt:Amet_2314.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AMET293826:GI5P-2358-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Alkaliphilus metalliredigens QYMF."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QYMF.

Entry informationi

Entry nameiSYL_ALKMQ
AccessioniPrimary (citable) accession number: A6TQK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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