A6TPR2 (A6TPR2_ALKMQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 1 HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase 1 HAMAP MF_01543

Gene names

Name:	fhs1 HAMAP MF_01543
Ordered Locus Names:	Amet_2018

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ABR48180.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	67 – 74	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A6TPR2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: EB8E24303BE5BE73	FASTA	558	59,809
	10 20 30 40 50 60 MSFKSDIEIA QEAKLQDIRE IAAKLNLTEE DIELYGKYKA KVDYNLLKKG NGQKKTKLIL 70 80 90 100 110 120 TTAINPTPAG EGKTTTTIGV ADGLARLGKK TIVALREPSL GPVFGVKGGA AGGGYAQVVP 130 140 150 160 170 180 MEDINLHFTG DFHAIGAANN LLAAMLDNHI NHGNKLEIDN RKITWRRAMD MNDRQLRNLV 190 200 210 220 230 240 NGMGGKGNGV VREDGFDITV ASEVMAAFCL ANDIVDLKGK LGDIIVAYTR DEKPVTAKDL 250 260 270 280 290 300 NAHGAMAALL KDALKPNLVQ TLEGTPAFVH GGPFANIAHG CNSVIATKMA MHFADYVVTE 310 320 330 340 350 360 AGFGADLGAE KFLDIKCRKS DLKPDVVIIV ATVRALKYNG GVAKDQLSQE NLEALENGLP 370 380 390 400 410 420 NLLKHVENIT KVFKLPAVVA INRFPLDTEA ELDLVRNKCK ELGVNVALSE VWADGGAGGE 430 440 450 460 470 480 ELAKEVLRLA EQESQLEYAY SLDMAIAEKI KAIATKIYGA DGVDFTPGAL KEMNKLEKLG 490 500 510 520 530 540 FGNLPICMAK TQYSLSDDAS LLGRPKGFNI TVRQIKVSAG AGFIVAITGE IMTMPGLPKV 550 PAAERIDVDE TGVITGLF

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR48180.1.
RefSeq	YP_001319839.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TPR2.
SMR	A6TPR2. Positions 6-556.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TPR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5312089.
GenomeReviews	Gene locus Amet_2018 in contig CP000724_GR.
KEGG	amt:Amet_2018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6TPR2_ALKMQ

Accession

Primary (citable) accession number: A6TPR2

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)