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Protein

Polyribonucleotide nucleotidyltransferase 3

Gene

pnp3

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi483MagnesiumUniRule annotation1
Metal bindingi489MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase 3UniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylase 3UniRule annotation
Short name:
PNPase 3UniRule annotation
Gene namesi
Name:pnp3UniRule annotation
Ordered Locus Names:Amet_1737
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000001572 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294931 – 702Polyribonucleotide nucleotidyltransferase 3Add BLAST702

Interactioni

Protein-protein interaction databases

STRINGi293826.Amet_1737.

Structurei

3D structure databases

ProteinModelPortaliA6TNZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini550 – 609KHUniRule annotationAdd BLAST60
Domaini619 – 687S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiWDLPEAS.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKTFEMKLG GRPFVVEIGK VAELAQGSCM IKYGDTTVLV TACASKEPKE
60 70 80 90 100
GLDFFPLSCD YEEKLYAVGK IPGGFIKRES RPSEKATLTA RLIDRPIRPL
110 120 130 140 150
FPKGYHNDVQ VIATVLSMDQ DCPPDISAMI GSSIALSVSN IPFMGPTASV
160 170 180 190 200
SVGMIDGEYI VNPTSKQKED STLELIVSGT KNAIMMIEAG ANELTEAQIL
210 220 230 240 250
DAIMFAHEEI KKIVAFIENI VSEVGKPKSE VIAKQMDSNL LTEVVIFLDT
260 270 280 290 300
KLANAIKTFD KTERNENIQA VSAEALDYFE EKYEGRSKEV HDILSMLIKV
310 320 330 340 350
ETRKMITSEG IRPDNRKLDE IRPISTQVGI LPRAHGTGLF NRGETQVLTI
360 370 380 390 400
TTLGDLRDAQ RIDGIGEEDE KRYMHHYNFP PYSVGETRFM RGPSRREIGH
410 420 430 440 450
GALVERALLP MIPSKEDFPY AIRLVSEVLT CNGSSSQASV CGSTLSLMDA
460 470 480 490 500
GVPIKRMVAG IAMGLIKEDD QVVILSDIQG MEDALGDMDL KVAGTEEGIT
510 520 530 540 550
AMQMDIKIAG IDRGIMETAL EQARIGRLHI LNKMKESITS PRIELSSYAP
560 570 580 590 600
KVTQIKVHPD KVREVIGAGG KVINKIIDET GCKITIENDG TIYVAAPDQE
610 620 630 640 650
SSRRAVEMIE LIVKDPVVGE VYTGKVIKIM DFGAFVEILP GKEGLVHISN
660 670 680 690 700
LAHERVTKVT DVLAEGDLIE VKLMEINPQG KIGLSRKALL PKPETKSETQ

SE
Length:702
Mass (Da):77,005
Last modified:August 21, 2007 - v1
Checksum:iFB9D8405466C69E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA. Translation: ABR47913.1.
RefSeqiWP_012062951.1. NC_009633.1.

Genome annotation databases

EnsemblBacteriaiABR47913; ABR47913; Amet_1737.
KEGGiamt:Amet_1737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA. Translation: ABR47913.1.
RefSeqiWP_012062951.1. NC_009633.1.

3D structure databases

ProteinModelPortaliA6TNZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi293826.Amet_1737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR47913; ABR47913; Amet_1737.
KEGGiamt:Amet_1737.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiWDLPEAS.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP3_ALKMQ
AccessioniPrimary (citable) accession number: A6TNZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.