A6TNX2 (SYR_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Amet_1714

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000198868
Regions
	Motif	123 – 133	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A6TNX2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: F9D4CEF14B37CAB2	FASTA	566	64,448
	10 20 30 40 50 60 MSDFKQKVSE LLGTQIEGIG QRELLEMIEV PPNSEMGDFA FPCFRLAKTF RKAPQVIAEE 70 80 90 100 110 120 LVAKIQLTDD FEKVDNTGGY LNFFVNRNTY AKAVIQEVLS KGDQYGSRNL GEGKNICIDY 130 140 150 160 170 180 SAPNVAKPFH VGHLRSTVIG NSLYRIYDFL GYNCIGINHL GDWGTQFGKV IVAYKNWGDK 190 200 210 220 230 240 AEIEKEPINT LLALYVKFHD EAEKNPDLED EARGWFTKME KGDEEALSLW KWFSSETIKE 250 260 270 280 290 300 LKKIYALLDV HFDHYSGESF YNDKMDVVID ELNKQNLLKE SQGANIVDLE EYNMPPCLVQ 310 320 330 340 350 360 KKDGSTLYAT RDIAAAIYRK NTFNFEKCLY VTDYSQNLHF AQWFKVIELM GYDWAKDIEH 370 380 390 400 410 420 ISFGRVTHEG RRIQSRKGSV VLLEEVLNGA VERISEIIEE KNPNVENKEQ VAKDVGIGAI 430 440 450 460 470 480 VFNDLSNNRI KDISFSWDTA FSFEGETGPY VQYTHARASS VLRKAEVAIT DHINAAHLTD 490 500 510 520 530 540 DVTMNVIKTI EQFPQVIVDA QRKNEPSIIT RHIVNIAQAF NRFYHDHPIL VEDEELKMAR 550 560 LAVVQAVKQV LSVGLSLIGI KAPEKM

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR47890.1.
RefSeq	YP_001319549.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TNX2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TNX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5311768.
GenomeReviews	Gene locus Amet_1714 in contig CP000724_GR.
KEGG	amt:Amet_1714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HBG695395.
OMA	FHEEAEK.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_1714-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ALKMQ

Accession

Primary (citable) accession number: A6TNX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program