A6TN07 (G6PI_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Amet_1375

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000060391
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6TN07 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 013BF90FF52BBEA8	FASTA	450	50,517
	10 20 30 40 50 60 MSGIRFDYSK ASGYINTHEL DYLGKMTETA HQLLHEKTGA GNEFLGWLDL PKNYDQDEFQ 70 80 90 100 110 120 RVQNCAEKIK NDSDVLIVIG IGGSYLGSRA AIEMLTHTFH NSLPKDKRQG PEVYFAGHNI 130 140 150 160 170 180 SSTYLKHLLD IIEGKDISLN VISKSGTTTE PALAFRVLKE YMEKKYGKEE TTKRIYATTD 190 200 210 220 230 240 QAKGALKQLA DEEGYESFII PDDVGGRFSV LTAVGLLPIA AAGINIEEVM QGAKQALQDF 250 260 270 280 290 300 NHSNIDKNSC YQYAIVRNAL YRKGKTTEIM VNYEPALHYI GEWWKQLFGE SEGKDQKGIF 310 320 330 340 350 360 PASVSFSTDL HSMGQYIQEG MRNIFETVLH VENTQEKMII QPTDADLDGL NYLAGKTVDF 370 380 390 400 410 420 VNEKAFEGTL LAHTDGGVPN LIIHIPEITP YYFGYLVYFF EKACAISGYL LGVNPFDQPG 430 440 450 VEAYKKNMFA LLGKPGFEEA QRELQKRLEK

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR47575.1.
RefSeq	YP_001319234.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TN07.
SMR	A6TN07. Positions 3-448.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TN07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5311426.
GenomeReviews	Gene locus Amet_1375 in contig CP000724_GR.
KEGG	amt:Amet_1375.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	GQGNDFL.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_1375-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ALKMQ

Accession

Primary (citable) accession number: A6TN07

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program