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A6TMY6 (GCST_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:Amet_1354
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Aminomethyltransferase HAMAP MF_00259
PRO_1000059077

Sequences

Sequence LengthMass (Da)Tools
A6TMY6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 116842D270673ED2

FASTA36941,950
        10         20         30         40         50         60 
MENSKKTPLF TVYEKHKGKL IDFGGWAMPV QFEGIIPEHE AVRSNAGLFD VSHMGEVEIK 

        70         80         90        100        110        120 
GKDALNFVQY LITNDASQME KNQIIYSFMC YENGGVVDDL LVYKFEEDYF YLVINAGNIE 

       130        140        150        160        170        180 
KDYEWMLKQS TAYDVEVNNI SNDVSELALQ GPKAEKILQK LTETDLSQLQ FFYLQRDVTI 

       190        200        210        220        230        240 
DGVNCLISRT GYTGEDGFEI YVNPSDAVQL WEKLLEVGQE DGLKPIGLGA RDTLRFEAAL 

       250        260        270        280        290        300 
PLYGHEINRD ITPLEAGFGF AVKLKKEVDF LGKKALIEQK EAGLTRKLVG FEMKDRGIPR 

       310        320        330        340        350        360 
SDYEVYHQGE KIGFVTTGYF SPTLKRNIGL ALIDAKYAEL GNEVDILIRK KQVKAELISK 


TFYKKNYKK

« Hide

References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000724 Genomic DNA. Translation: ABR47554.1.
RefSeqYP_001319213.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TMY6.
SMRA6TMY6. Positions 5-362.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TMY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5311405.
GenomeReviewsGene locus Amet_1354 in contig CP000724_GR.
KEGGamt:Amet_1354.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHBG299834.
OMAKALYGGM.
ProtClustDBPRK00389.

Enzyme and pathway databases

BioCycAMET293826:AMET_1354-MONOMER.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_ALKMQ
AccessionPrimary (citable) accession number: A6TMY6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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