ID   A6TMS8_ALKMQ            Unreviewed;       475 AA.
AC   A6TMS8;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=Uronate isomerase {ECO:0000256|ARBA:ARBA00020555, ECO:0000256|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000256|ARBA:ARBA00012546, ECO:0000256|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000256|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000256|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000256|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=Amet_1291 {ECO:0000313|EMBL:ABR47496.1};
OS   Alkaliphilus metalliredigens (strain QYMF).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Alkaliphilus.
OX   NCBI_TaxID=293826 {ECO:0000313|EMBL:ABR47496.1, ECO:0000313|Proteomes:UP000001572};
RN   [1] {ECO:0000313|Proteomes:UP000001572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QYMF {ECO:0000313|Proteomes:UP000001572};
RX   PubMed=27811105; DOI=10.1128/genomeA.01226-16;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina Del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F.,
RA   Land M.L., Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J.,
RA   Richardson P., Fields M.W.;
RT   "Complete genome sequence of Alkaliphilus metalliredigens strain QYMF, an
RT   alkaliphilic and metal-reducing bacterium isolated from borax-contaminated
RT   leachate ponds.";
RL   Genome Announc. 4:0-0(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001165, ECO:0000256|HAMAP-
CC         Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000256|ARBA:ARBA00004892, ECO:0000256|HAMAP-
CC       Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000256|ARBA:ARBA00008397,
CC       ECO:0000256|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000724; ABR47496.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6TMS8; -.
DR   STRING; 293826.Amet_1291; -.
DR   KEGG; amt:Amet_1291; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001572; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 1.10.2020.10; uronate isomerase, domain 2, chain A; 1.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   PANTHER; PTHR30068; URONATE ISOMERASE; 1.
DR   PANTHER; PTHR30068:SF4; URONATE ISOMERASE; 1.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00675};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001572}.
SQ   SEQUENCE   475 AA;  55077 MW;  EF5BC0D590044FCA CRC64;
     MKGMIKISFI NNDFMLENEI ARHLYHTYAK SLPIFDYHCH LNTQHIAEDH EFADITELWL
     AGDHYKWRAM RGNGVSEEKI TGKASSEEKF QAWAETVESC VGNPLYHWTH LELKAYFGID
     ELLKRSNWKS IYDRANKIIK EEGLTVRKLI KQSNVDFICT TDDPIDSLEF HDEIAKDEDF
     KVKVVPTFRP DGAFGIGEET FIDFIDKLGD LTSLPISSYQ EMLVGIEARI DYFDKKGALI
     SDHGLEKLVY IESTDEEIEN IFQKALGKKE MTEEDYGKFI TRLLIDLGKI YYHKDWIMQI
     HFGAIRNNNS KMYELVGENT GFDSIVDQSN VAYALNRLLD AMSRKNCLPK TVVYNLNPDY
     NHIVASAVSN FQDNEEGIRG KVQFGAGWWF NDTEQGMLRQ MSTLADHGLL MNFVGMLTDS
     RSFISYPRHE YFRRILCNYV GVQVENGKFP NDEELLKRLI ENICYYNAVN YFTKK
//