Reviewed, UniProtKB/Swiss-Prot A6TM74 (TRPC_ALKMQ)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Amet_1080

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000057869

Sequences

	Sequence		Length	Mass (Da)
	A6TM74-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: C85156863CF02C62	FASTA	261	29,430
	10 20 30 40 50 60 MILDKIIRYK KNKVKEEKVA VPLGEIMKQI EDMEEARNFK AALVGRESIS MIAEVKKASP 70 80 90 100 110 120 SKGIIKKDFN PVKIAAEYEK NRVDAISVLT EDQFFLGDNR YLQDIRKMTT IPLLRKDFMI 130 140 150 160 170 180 DAYQIYQSKA LGADAILLIA AALTKKEMIA FQKIAAEIGI YSLVEVHNKE ELEMILETGA 190 200 210 220 230 240 EIIGINNRDL KTFDTTLDRT AELLPFIPKD KIVVSESGIK TNQDMKLLKN YGINAVLMGE 250 260 GLMRADSIGE KLRELRSGLC D

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR47292.1.
RefSeq	YP_001318951.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TM74.
Genome annotation databases
GeneID	5311131.
GenomeReviews	Gene locus Amet_1080 in contig CP000724_GR.
KEGG	amt:Amet_1080.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PLLCKDF.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ALKMQ

Accession

Primary (citable) accession number: A6TM74

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)