Reviewed, UniProtKB/Swiss-Prot A6TLS5 (PUR5_ALKMQ)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Amet_0923

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000072814

Sequences

	Sequence		Length	Mass (Da)
	A6TLS5-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 786EF85DE2EEDF72	FASTA	347	37,704
	10 20 30 40 50 60 MAMPKLTYEE AGVNVQEGQR AVNLMKESVK STFTKGVLGD IGGFGGLFAL DPREMEKPIL 70 80 90 100 110 120 VAGTDGVGTK LKLAFMMNRH DTIGEDCVAM CVNDILCQGA KPLFFLDYIA TGKLKAEVVA 130 140 150 160 170 180 EIVQGIANGC KKAGCALIGG ETAEMPGFYQ KGEYDVAGFT VGMVEEKNLI TGKEISQGDI 190 200 210 220 230 240 MIGISSSGVH SNGFSLVRKL FFEDKQYSVD QYVDGLGETL GEALLRPTKI YVKPILEVLQ 250 260 270 280 290 300 QEKIKGMVHV TGGGFYENIP RILPEGIDAN VHLDTWQAPP IFQFIQQEGQ IEQDEMFSTF 310 320 330 340 NMGIGMIVVV ERSAGEKVVQ LLQELGEEAS IIGEMVRGSK QVVLCQK

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR47143.1.
RefSeq	YP_001318802.1.
3D structure databases
SMR	A6TLS5. Positions 20-340.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TLS5.
Genome annotation databases
GeneID	5310966.
GenomeReviews	Gene locus Amet_0923 in contig CP000724_GR.
KEGG	amt:Amet_0923.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HBG531222.
OMA	VHGLAHI.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ALKMQ

Accession

Primary (citable) accession number: A6TLS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)