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A6TL10

- ASSY_ALKMQ

UniProt

A6TL10 - ASSY_ALKMQ

Protein

Argininosuccinate synthase

Gene

argG

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901CitrullineUniRule annotation
    Binding sitei95 – 951CitrullineUniRule annotation
    Binding sitei120 – 1201ATP; via amide nitrogenUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei130 – 1301CitrullineUniRule annotation
    Binding sitei179 – 1791CitrullineUniRule annotation
    Binding sitei188 – 1881CitrullineUniRule annotation
    Binding sitei264 – 2641CitrullineUniRule annotation
    Binding sitei276 – 2761CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMET293826:GI5P-670-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Amet_0653
    OrganismiAlkaliphilus metalliredigens (strain QYMF)
    Taxonomic identifieri293826 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
    ProteomesiUP000001572: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Argininosuccinate synthasePRO_0000321299Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi293826.Amet_0653.

    Structurei

    3D structure databases

    ProteinModelPortaliA6TL10.
    SMRiA6TL10. Positions 8-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6TL10-1 [UniParc]FASTAAdd to Basket

    « Hide

    METKNKKKVV LAYSGGLDTS VILKWLEETY GYEVIAACVN VGQTEDFAAI    50
    KKKALATGAS KAYIVDVTEE FITDYIFPTL KAGAVYEDDY LLGTSFARPL 100
    ISKKLVEIAE KEGAVAIAHG ATGKGNDQVR FEATIKALNP NLKIIAPWRT 150
    WDLKSREDCI DYAVQHGIPI PVTKKDIYSR DENIWHISHE GGNLENPWNE 200
    HDDTIYKLSV SPEKSPDTPT YVELEFYKGI PVAVDGVKYE PIDMLTTLNK 250
    LGGAHGVGII DIVENRLVGM KSRGVYETPG GTLLFAAHKA LEKLTLDRDT 300
    TSFKKGISVK YAQLVYDGLW HTPLKDALDQ FVNSTQEFVT GQVKLKLYKG 350
    NCTAVASASP FSLYNEDFVT FGEDHVYNQQ DAEGFINLFA LPLTIRALML 400
    EEKLQGEAKE KKII 414
    Length:414
    Mass (Da):45,983
    Last modified:August 21, 2007 - v1
    Checksum:i47FCF9714C88AAA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000724 Genomic DNA. Translation: ABR46878.1.
    RefSeqiYP_001318537.1. NC_009633.1.

    Genome annotation databases

    EnsemblBacteriaiABR46878; ABR46878; Amet_0653.
    GeneIDi5310696.
    KEGGiamt:Amet_0653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000724 Genomic DNA. Translation: ABR46878.1 .
    RefSeqi YP_001318537.1. NC_009633.1.

    3D structure databases

    ProteinModelPortali A6TL10.
    SMRi A6TL10. Positions 8-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293826.Amet_0653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR46878 ; ABR46878 ; Amet_0653 .
    GeneIDi 5310696.
    KEGGi amt:Amet_0653.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci AMET293826:GI5P-670-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Alkaliphilus metalliredigens QYMF."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: QYMF.

    Entry informationi

    Entry nameiASSY_ALKMQ
    AccessioniPrimary (citable) accession number: A6TL10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3