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A6TL10

- ASSY_ALKMQ

UniProt

A6TL10 - ASSY_ALKMQ

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Protein

Argininosuccinate synthase

Gene
argG, Amet_0653
Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Citrulline By similarity
Binding sitei95 – 951Citrulline By similarity
Binding sitei120 – 1201ATP; via amide nitrogen By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei179 – 1791Citrulline By similarity
Binding sitei188 – 1881Citrulline By similarity
Binding sitei264 – 2641Citrulline By similarity
Binding sitei276 – 2761Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMET293826:GI5P-670-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Amet_0653
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
ProteomesiUP000001572: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Argininosuccinate synthaseUniRule annotationPRO_0000321299Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi293826.Amet_0653.

Structurei

3D structure databases

ProteinModelPortaliA6TL10.
SMRiA6TL10. Positions 8-399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TL10-1 [UniParc]FASTAAdd to Basket

« Hide

METKNKKKVV LAYSGGLDTS VILKWLEETY GYEVIAACVN VGQTEDFAAI    50
KKKALATGAS KAYIVDVTEE FITDYIFPTL KAGAVYEDDY LLGTSFARPL 100
ISKKLVEIAE KEGAVAIAHG ATGKGNDQVR FEATIKALNP NLKIIAPWRT 150
WDLKSREDCI DYAVQHGIPI PVTKKDIYSR DENIWHISHE GGNLENPWNE 200
HDDTIYKLSV SPEKSPDTPT YVELEFYKGI PVAVDGVKYE PIDMLTTLNK 250
LGGAHGVGII DIVENRLVGM KSRGVYETPG GTLLFAAHKA LEKLTLDRDT 300
TSFKKGISVK YAQLVYDGLW HTPLKDALDQ FVNSTQEFVT GQVKLKLYKG 350
NCTAVASASP FSLYNEDFVT FGEDHVYNQQ DAEGFINLFA LPLTIRALML 400
EEKLQGEAKE KKII 414
Length:414
Mass (Da):45,983
Last modified:August 21, 2007 - v1
Checksum:i47FCF9714C88AAA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000724 Genomic DNA. Translation: ABR46878.1.
RefSeqiYP_001318537.1. NC_009633.1.

Genome annotation databases

EnsemblBacteriaiABR46878; ABR46878; Amet_0653.
GeneIDi5310696.
KEGGiamt:Amet_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000724 Genomic DNA. Translation: ABR46878.1 .
RefSeqi YP_001318537.1. NC_009633.1.

3D structure databases

ProteinModelPortali A6TL10.
SMRi A6TL10. Positions 8-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293826.Amet_0653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR46878 ; ABR46878 ; Amet_0653 .
GeneIDi 5310696.
KEGGi amt:Amet_0653.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci AMET293826:GI5P-670-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Alkaliphilus metalliredigens QYMF."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QYMF.

Entry informationi

Entry nameiASSY_ALKMQ
AccessioniPrimary (citable) accession number: A6TL10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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