Reviewed, UniProtKB/Swiss-Prot A6TL09 (ARLY_ALKMQ)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Amet_0652

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Argininosuccinate lyase HAMAP MF_00006		PRO_1000057046

Sequences

	Sequence		Length	Mass (Da)
	A6TL09-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 719DF1810AD418D0	FASTA	460	52,003
	10 20 30 40 50 60 MKLWGGRFSK NTAALVDQFN ASIEFDQKLY KYDIAGSVAH AKMLAHANII TKQESQLIVE 70 80 90 100 110 120 GLQSILADIE AGKVEFQLEL EDIHMNIETL LIDSIGEVGK KLHTARSRND QVAVDIRLYL 130 140 150 160 170 180 REEILEICEL IKQLLITFTD IAEKHVDTIM PGYTHLQRAQ AVTLGHHFMA YFQMFKRDHE 190 200 210 220 230 240 RLLDCYKRVN VMPLGAGALA GTTYATDRVF LAKELGFDAI CENSLDAVSD RDFIIEFNNT 250 260 270 280 290 300 ASIIMMHLSR FCEELIIWNT AEFGFIEMDD AYSTGSSIMP QKKNPDLAEL IRGKTGRVYG 310 320 330 340 350 360 NQVNIMTMMK ALPLAYNKDM QEDKIPLFDT VDNVKGCLEI FNEMIKSTTF KKENMKKATK 370 380 390 400 410 420 EGFMNATDVA DYLVKKGVPF RSAHEIVGKM VLHCVQTSKT IEDLTLDEFQ NFSPTFTEDI 430 440 450 460 LEVIQIENCV ASKISQGSTS PTNVLIMVNQ ARVFIEEVLS

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR46877.1.
RefSeq	YP_001318536.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TL09.
Genome annotation databases
GeneID	5310695.
GenomeReviews	Gene locus Amet_0652 in contig CP000724_GR.
KEGG	amt:Amet_0652.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ALKMQ

Accession

Primary (citable) accession number: A6TL09

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)