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A6TL07 (AROB_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Amet_0650
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3563563-dehydroquinate synthase HAMAP MF_00110
PRO_1000094450

Sequences

Sequence LengthMass (Da)Tools
A6TL07 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A4F6DC44C44173C4

FASTA35639,846
        10         20         30         40         50         60 
MEKLYINLDE NSYWIYIGKG LLPTLGKHVA GADKILLITD ENVEKYYGDQ ITQIVEGRIL 

        70         80         90        100        110        120 
EKVILRPGEP TKNLGNVGHL LEIMLEKGLT RSSKVIALGG GVIGDIAGFT ASIYMRGIDF 

       130        140        150        160        170        180 
IQVPTTLLAQ VDSSVGGKTG VNLEQGKNMV GSFYQPKVVV IDIDLLKTLP HRELISGLGE 

       190        200        210        220        230        240 
IIKYGIIYDG EFFDYINENL WNLLALEETV VTKIIKRCCE IKAAIVSQDE QEMGVRKILN 

       250        260        270        280        290        300 
FGHTIGHGIE ALTHYEKYTH GEAVILGMYY EAQIAKNRGY IDESYFRDIE MIIRKTGLDL 

       310        320        330        340        350 
NISQFILTDL LDAMTKDKKN KGGKISFILP RGKGNVQEVL LTPEELATFL YTYLYV

« Hide

References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000724 Genomic DNA. Translation: ABR46875.1.
RefSeqYP_001318534.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TL07.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TL07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5310693.
GenomeReviewsGene locus Amet_0650 in contig CP000724_GR.
KEGGamt:Amet_0650.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMATERMISD.

Enzyme and pathway databases

BioCycAMET293826:AMET_0650-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ALKMQ
AccessionPrimary (citable) accession number: A6TL07
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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