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A6TL06 (AROC_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Amet_0649
OrganismAlkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]
Taxonomic identifier293826 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Chorismate synthase HAMAP MF_00300
PRO_0000322384

Sequences

Sequence LengthMass (Da)Tools
A6TL06 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 77F76EDFD1E65BDC

FASTA38042,128
        10         20         30         40         50         60 
MFRLLTAGES HGKSLVGVIE GFPANVKIDI EEINRDLGRR QRGYGRGGRM KIEKDRVEIL 

        70         80         90        100        110        120 
SGVRGGKTLG SPISFLIENK DYANWEPYMN PEAVDGEEKR VTQPRPGHGD LTGTLKYGFD 

       130        140        150        160        170        180 
DIRNVLERSS ARETAVRVAI GSLAKQLMRE FHIEVYSHVT AIGSVSLGEP VENIEKIKRA 

       190        200        210        220        230        240 
EDSEVRCLDP EVEKAMIEEI KRAKEEGDSL GGIFEIHVTG VPRGLGSYVQ WDHKLDAKLA 

       250        260        270        280        290        300 
HALMSIQAIK GVEVGCGFDQ AQKKGSQVHD EIFFSQEKDY YRKTNYAGGI EGGMSNGENI 

       310        320        330        340        350        360 
HLRCAMKPIP TLYKPLRTVD IETKEAVLAT VERSDSCAVP AASIVGEMVA ITVIAQEFLK 

       370        380 
KFGSDSLEEI RKTWKSYTSI

« Hide

References

[1]"Complete sequence of Alkaliphilus metalliredigens QYMF."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QYMF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000724 Genomic DNA. Translation: ABR46874.1.
RefSeqYP_001318533.1. NC_009633.1.

3D structure databases

ProteinModelPortalA6TL06.
SMRA6TL06. Positions 2-378.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TL06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5310692.
GenomeReviewsGene locus Amet_0649 in contig CP000724_GR.
KEGGamt:Amet_0649.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycAMET293826:AMET_0649-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ALKMQ
AccessionPrimary (citable) accession number: A6TL06
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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