Reviewed, UniProtKB/Swiss-Prot A6TL06 (AROC_ALKMQ)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Amet_0649

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Chorismate synthase HAMAP MF_00300		PRO_0000322384

Sequences

	Sequence		Length	Mass (Da)
	A6TL06-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 77F76EDFD1E65BDC	FASTA	380	42,128
	10 20 30 40 50 60 MFRLLTAGES HGKSLVGVIE GFPANVKIDI EEINRDLGRR QRGYGRGGRM KIEKDRVEIL 70 80 90 100 110 120 SGVRGGKTLG SPISFLIENK DYANWEPYMN PEAVDGEEKR VTQPRPGHGD LTGTLKYGFD 130 140 150 160 170 180 DIRNVLERSS ARETAVRVAI GSLAKQLMRE FHIEVYSHVT AIGSVSLGEP VENIEKIKRA 190 200 210 220 230 240 EDSEVRCLDP EVEKAMIEEI KRAKEEGDSL GGIFEIHVTG VPRGLGSYVQ WDHKLDAKLA 250 260 270 280 290 300 HALMSIQAIK GVEVGCGFDQ AQKKGSQVHD EIFFSQEKDY YRKTNYAGGI EGGMSNGENI 310 320 330 340 350 360 HLRCAMKPIP TLYKPLRTVD IETKEAVLAT VERSDSCAVP AASIVGEMVA ITVIAQEFLK 370 380 KFGSDSLEEI RKTWKSYTSI

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR46874.1.
RefSeq	YP_001318533.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TL06.
Genome annotation databases
GeneID	5310692.
GenomeReviews	Gene locus Amet_0649 in contig CP000724_GR.
KEGG	amt:Amet_0649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PPGLGSH.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ALKMQ

Accession

Primary (citable) accession number: A6TL06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)