Reviewed, UniProtKB/Swiss-Prot A6TL04 (AROA_ALKMQ)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Amet_0647

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325328

Sequences

	Sequence		Length	Mass (Da)
	A6TL04-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 999BE1EBC8F4004F	FASTA	425	45,468
	10 20 30 40 50 60 MLVTNKVEKL EGKMTVPGDK SISHRAIMLS SISKGTSRVK GFLRGEDCLS TISCFRDLGI 70 80 90 100 110 120 DIEDRGTEII IQGKGLHGLS EPLNVLDAGN SGTTIRLISG ILAGQKFLTI VTGDASLRKR 130 140 150 160 170 180 PMERIATPLR KMGAFIEGRD YGNLAPLVIR GGNLKGMDYA SPVSSAQVKS AILLAGLYGE 190 200 210 220 230 240 GDTIVREKIT SRDHTEKMLK GLGANISTDQ GVTRLGKSEL YGQSIEVPGD ISSAAFFMAG 250 260 270 280 290 300 AAALPGSFLI TEGVGLNPTR TGIIDVLRDM GGDIEIHNLR QSGGEEIGDI MIRGKKLYGT 310 320 330 340 350 360 EIGKEIIPRL IDEIPVLAII AATAEGKTII TGAEELKVKE SNRITAMVTE MQKVGIKVTE 370 380 390 400 410 420 LPDGMEIEGG QVITGGRVES YGDHRIAMAM AICGLFAQEP IKINDSQCID ISFPNFEEKL KAVVR

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR46872.1.
RefSeq	YP_001318531.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TL04.
Genome annotation databases
GeneID	5310690.
GenomeReviews	Gene locus Amet_0647 in contig CP000724_GR.
KEGG	amt:Amet_0647.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NPTRIEA.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ALKMQ

Accession

Primary (citable) accession number: A6TL04

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)