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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAMET293826:G1G94-87-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Amet_0070
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000001572 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000622441 – 377Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST377

Interactioni

Protein-protein interaction databases

STRINGi293826.Amet_0070

Structurei

3D structure databases

ProteinModelPortaliA6TJE5
SMRiA6TJE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A6TJE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERYIIKDGK KLRYGYTTGS CATAASKAAA QMLLQPGEVH EVDIDTPKGW
60 70 80 90 100
SLKLKVEDIQ RSHGAVSCAI IKDAGDDPDV TNKLAIYSKL IWRQDTKIEI
110 120 130 140 150
HGGEGVGTVT RPGLQIPVGK PAINPIPLQM IEREVREVIG PGRGVDIVIS
160 170 180 190 200
VPKGQEVAKK TFNPKLGIQG GISILGTSGI VEPMSEEAMK DSLALELPMA
210 220 230 240 250
KAEKIKTFVF VPGNYGRDMA REKYKIHDKN MIKISNFVGF MMDQSVIQNV
260 270 280 290 300
ERILIIGHIG KLVKVAGGIF HTHSKVADGR REILAAHLAA LGASQQLVLR
310 320 330 340 350
VLESNTTEEA VGLIQEKGFD RLFSHLADKI TEKCVERTQG NIEIGTIIFS
360 370
MEQGVLAHCS QAGRLLEILK SEGVKDE
Length:377
Mass (Da):41,119
Last modified:August 21, 2007 - v1
Checksum:i35DCC610478A3C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA Translation: ABR46313.1
RefSeqiWP_011971222.1, NC_009633.1

Genome annotation databases

EnsemblBacteriaiABR46313; ABR46313; Amet_0070
KEGGiamt:Amet_0070

Similar proteinsi

Entry informationi

Entry nameiCBID_ALKMQ
AccessioniPrimary (citable) accession number: A6TJE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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