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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:KPN78578_47570
ORF Names:KPN_04838
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000696631 – 440Thymidine phosphorylaseAdd BLAST440

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_04838

Structurei

3D structure databases

ProteinModelPortaliA6THZ7
SMRiA6THZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA
HOGENOMiHOG000047313
KOiK00758
OMAiVHSIGGV

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6THZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAQEIIRK KRDGQALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD
60 70 80 90 100
MSMPERVSLT MAMRDSGTVL DWKSLNLNGP IVDKHSTGGV GDVTSLMLGP
110 120 130 140 150
MVAACGGYVP MISGRGLGHT GGTLDKLEAI PGFDIFPDDN RFREIIKDVG
160 170 180 190 200
VAIIGQTSSL APADKRFYAT RDITATVDSI PLITASILAK KLAEGLDALV
210 220 230 240 250
MDVKVGSGAF MPTYELSAAL AEAIVGVANG AGVRTTALLT DMNQVLASSA
260 270 280 290 300
GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGKLA ADDAEARAKL
310 320 330 340 350
QAVLDNGKAA EVFGRMVAAQ KGPSDFVENY ANYLPTAMLS KAVYADTEGF
360 370 380 390 400
ISAMDTRALG MAVVSMGGGR RQASDTIDYS VGFTEMARLG DRVDGQRPLA
410 420 430 440
VIHAKDENSW QEAAKAVKAA IKLDDKAPEI TPTVYRRITE
Length:440
Mass (Da):47,045
Last modified:August 21, 2007 - v1
Checksum:i3FA3DBB57876B640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR80181.1

Genome annotation databases

EnsemblBacteriaiABR80181; ABR80181; KPN_04838
KEGGikpn:KPN_04838

Similar proteinsi

Entry informationi

Entry nameiTYPH_KLEP7
AccessioniPrimary (citable) accession number: A6THZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health