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Protein

Inosose dehydratase

Gene

iolE

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-4714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:KPN78578_46040
ORF Names:KPN_04677
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Inosose dehydratasePRO_0000352371Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_04677.

Structurei

3D structure databases

ProteinModelPortaliA6THJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.
OrthoDBiEOG6HB9S9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6THJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKDNVKLAI APIGWTNDDM PELGSENTFQ QIVSEMALAG FTGSEVGSKY
60 70 80 90 100
PRDPAVLKPM LDIRGIQICN AWFSTFFANG QREKTIDEFV NHMNFLHAMG
110 120 130 140 150
AKVIGCSEQS GSIQGLDKPI LGDAKPCFSD EEWQRVAEGY NTLGRLAAEK
160 170 180 190 200
GMQVCLHHHM GTGIQTTAEI DKFMSLVDER VFLLFDTGHA WYSEGGEAPM
210 220 230 240 250
LAILKKYLPR INHVHLKDVR PPVIDQVRRD GLSFLDGVKK GTFTVPGDGV
260 270 280 290
IDFRPVFKLL DDFGYKGWMV VEAEQDPALA NPFEYAVKAR KYIRETAGI
Length:299
Mass (Da):33,316
Last modified:August 21, 2007 - v1
Checksum:iF99B30E2FB28670E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR80028.1.
RefSeqiWP_002886970.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR80028; ABR80028; KPN_04677.
KEGGikpn:KPN_04677.
PATRICi20463826. VBIKlePne13394_4723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR80028.1.
RefSeqiWP_002886970.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6THJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_04677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR80028; ABR80028; KPN_04677.
KEGGikpn:KPN_04677.
PATRICi20463826. VBIKlePne13394_4723.

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.
OrthoDBiEOG6HB9S9.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-4714-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiIOLE_KLEP7
AccessioniPrimary (citable) accession number: A6THJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 21, 2007
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.