A6THJ2 (IOLG_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	KPN78578_46020
ORF Names:	KPN_04675

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.
Sequence caution	The sequence ABR80026.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352571

Sequences

	Sequence		Length	Mass (Da)
	A6THJ2 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 481CE0FA0CBBCE27	FASTA	337	36,782
	10 20 30 40 50 60 MSLKLGVIGA GAIGKEHIRR CTQVLQGATV VAVSDINADN ARAAVALPGV QAEVYADGHD 70 80 90 100 110 120 VINASDVDAI LVTSWDPTHE EYTLAAIAAG KPVFCEKPLA MTAEGCRRIV DAEMKAGRRL 130 140 150 160 170 180 VQVGFMRPYD EGYLALKKVI DDGDIGAPLM LRCAHRNQSV GENYTTDMAI TNTLIHELDV 190 200 210 220 230 240 LRWLLNDDYR SVQVRFPRST SHTHARLKDP QIVSFETKKG TLIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIARL PEPSAVQMRK SASLSTAILT DWKDRFIKAY DVELQAFIND VKAGQLHGPS 310 320 330 AWDGYAASVA ADACIKAQGT SEPVEVTLPE CPAFYKR

References

[1]

The Klebsiella pneumonia Genome Sequencing Project McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR80026.1. Different initiation.
RefSeq	YP_001338293.1. NC_009648.1.
3D structure databases
ProteinModelPortal	A6THJ2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6THJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5339524.
GenomeReviews	Gene locus KPN78578_46020 in contig CP000647_GR.
KEGG	kpn:KPN_04675.
PATRIC	20463822. VBIKlePne13394_4721.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
ProtClustDB	CLSK2792832.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_KLEP7

Accession

Primary (citable) accession number: A6THJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program