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A6TGG8

- GPPA_KLEP7

UniProt

A6TGG8 - GPPA_KLEP7

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, KPN78578_42280, KPN_04280
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-4317-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:KPN78578_42280
ORF Names:KPN_04280
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_1000068823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_04280.

Structurei

3D structure databases

ProteinModelPortaliA6TGG8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TGG8-1 [UniParc]FASTAAdd to Basket

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MSSTSLYAAI DLGSNSFHML VVREVAGSIQ TLSRIKRKVR LAAGLNSDNT    50
LSAEAMERGW QCLRLFAERL QDIPPTQIRV VATATLRLAV NAGEFLAKAQ 100
EILGTPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG 150
AQTTSLFSLS MGCVTWLERY FADRSLTKEN FDLAEAAARE VLLPVADVLR 200
YHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE 250
LEIEGLTLER ALVFPSGLAI LIAIFSELNI QCMTLAGGAL REGLVYGMLH 300
LSVEQDIRSR TLRNIQRRFM IDTEQAQRVG GLASHLLSQL DGSWELDPLS 350
RDLLLSACAL HEIGLSVDFK RAPQHAAYLV NNLDLPGFTP AQKKLIATLL 400
LNQTNAIDLS SLHQQNAVPP RVAEHLCRLL RLAILFASRR RDDLLPAIQL 450
TAQDEQLTLI LPGNWLDEHP LGREMVDQEC QWQSYVHWIL RVASGDTLK 499
Length:499
Mass (Da):55,010
Last modified:August 21, 2007 - v1
Checksum:i1B905D136187C178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR79652.1.
RefSeqiYP_001337919.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR79652; ABR79652; KPN_04280.
GeneIDi5339202.
KEGGikpn:KPN_04280.
PATRICi20463022. VBIKlePne13394_4342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR79652.1 .
RefSeqi YP_001337919.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TGG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_04280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR79652 ; ABR79652 ; KPN_04280 .
GeneIDi 5339202.
KEGGi kpn:KPN_04280.
PATRICi 20463022. VBIKlePne13394_4342.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci KPNE272620:GKDC-4317-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiGPPA_KLEP7
AccessioniPrimary (citable) accession number: A6TGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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