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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146UniRule annotation1
Active sitei554UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processCarbon dioxide fixationUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:KPN_04245Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)Imported
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_04245.

Structurei

3D structure databases

ProteinModelPortaliA6TGE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CCA. Bacteria.
COG2352. LUCA.
HOGENOMiHOG000238648.
KOiK01595.
OMAiPWVFGWT.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1. 1 hit.
InterProiView protein in InterPro
IPR021135. PEP_COase.
IPR022805. PEP_COase_bac/pln-type.
IPR018129. PEP_COase_Lys_AS.
IPR033129. PEPCASE_His_AS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF00311. PEPcase. 1 hit.
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiView protein in PROSITE
PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6TGE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWGVWGNMN EQYSALRSNV SMLGKVLGDT IKDALGENIL DRVETIRKLS
60 70 80 90 100
KSSRAGNEAN RQELLTTLQN LSNDELLPVA RAFSQFLNLA NTAEQYHSIS
110 120 130 140 150
ANGEAASNPE VIARTLRKLK DQPNLNEETI KQAVESLSLE LVLTAHPTEI
160 170 180 190 200
TRRTLIHKMV EVNNCLKQLD NKDIADYEHH QLMRRLRQLI AQSWHTDEIR
210 220 230 240 250
KHRPSPVDEA KWGFAVVENS LWEGVPNYLR ELNEQLEANL GYQLPVDFVP
260 270 280 290 300
VRFTSWMGGD RDGNPNVTAD ITRHVLLLSR WKATDLFLKD VQVLISELSM
310 320 330 340 350
VECTDELRAL AGAEGAQEPY RYLMKKLRSQ LMETQAWLEA RLKGQKLPKP
360 370 380 390 400
AGLITQNEQL WEPLYACYKS LQACGMGIIA NGELLDTLRR VKSFGVPLVR
410 420 430 440 450
IDIRQESTRH TEALGEMTRY LGIGDYESWS EADKQAFLIR ELNSKRPLLP
460 470 480 490 500
RQWEPSEETR EVLDTCKVIA EAPRGSIAAY VISMAKTPSD VLAVHLLLKE
510 520 530 540 550
AGIGFALPVA PLFETLDDLN NANDVMTQLL NIDWYRGFIQ GKQMVMIGYS
560 570 580 590 600
DSAKDAGVMA ASWAQYQAQD ALIKTCEKAG IELTLFHGRG GSIGRGGAPA
610 620 630 640 650
HAALLSQPPG SLKGGLRVTE QGEMIRFKYG LPEVTISSLS LYTSAILEAN
660 670 680 690 700
LLPPPEPKAE WRDIMAELSD VSCKMYRGYV RENKDFVPYF RSATPEQELG
710 720 730 740 750
KLPLGSRPAK RRPTGGVESL RAIPWIFAWT QNRLMLPAWL GAGAALQKVV
760 770 780 790 800
EGGKQSELEA MCRDWPFFST RLGMLEMVYS KADLWLAEYY DQRLVKPELW
810 820 830 840 850
ALGSELRKLL AADINVVLAI ANDSHLMADL PWIAESIQLR NIYTDPLNVL
860 870 880 890
QAELLHRSRQ AEEEGKDPDP RVEQALMVTI AGVAAGMRNT G
Length:891
Mass (Da):99,934
Last modified:August 21, 2007 - v1
Checksum:iAD82AC29CE687B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79624.1.

Genome annotation databases

EnsemblBacteriaiABR79624; ABR79624; KPN_04245.
KEGGikpn:KPN_04245.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA6TGE0_KLEP7
AccessioniPrimary (citable) accession number: A6TGE0
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported