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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 213H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi243 – 266H-T-H motifUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Ordered Locus Names:KPN78578_41700
ORF Names:KPN_04215
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198471 – 281HTH-type transcriptional activator RhaRAdd BLAST281

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei245Interaction with sigma-70UniRule annotation1

Protein-protein interaction databases

STRINGi272620.KPN_04215.

Structurei

3D structure databases

ProteinModelPortaliA6TGB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108BRW. Bacteria.
ENOG410XYX0. LUCA.
HOGENOMiHOG000290513.
KOiK02854.
OMAiDWAAHIP.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TGB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLILRKEE FFPSATQAVA VADRYPQNVF AEHTHEFCEL VLVWRGNGLH
60 70 80 90 100
VLNDRPWRIT RGDLFYIRAE DKHSYASVND LVLQNIIYCP ERLQLNFDWA
110 120 130 140 150
GAIPGLFGTP WKPHWRMGST GMAQARQVIS QLEHECARRD AQGNAMAELL
160 170 180 190 200
FAQLALTLQR HRYATDDPAA TQREALLDKL LAALAASLSR PFVLERFCEQ
210 220 230 240 250
EGGSERALRQ QFRQQTGMTI NHYLRQLRIC HAQYLLQHTE RLIGDIAMQC
260 270 280
GFEDSNYFSV VFSREIGMSP GQWRQRSRAA A
Length:281
Mass (Da):32,206
Last modified:August 21, 2007 - v1
Checksum:i542A0882ED497F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79594.1.
RefSeqiWP_002882891.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR79594; ABR79594; KPN_04215.
KEGGikpn:KPN_04215.
PATRICi20462888. VBIKlePne13394_4282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79594.1.
RefSeqiWP_002882891.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TGB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_04215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR79594; ABR79594; KPN_04215.
KEGGikpn:KPN_04215.
PATRICi20462888. VBIKlePne13394_4282.

Phylogenomic databases

eggNOGiENOG4108BRW. Bacteria.
ENOG410XYX0. LUCA.
HOGENOMiHOG000290513.
KOiK02854.
OMAiDWAAHIP.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHAR_KLEP7
AccessioniPrimary (citable) accession number: A6TGB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.