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Protein

HTH-type transcriptional activator RhaS

Gene

rhaS

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaBAD and rhaT operons.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi190 – 20920H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi239 – 26224H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-4251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaSUniRule annotation
Alternative name(s):
L-rhamnose operon regulatory protein RhaSUniRule annotation
Gene namesi
Name:rhaSUniRule annotation
Ordered Locus Names:KPN78578_41690
ORF Names:KPN_04214
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278HTH-type transcriptional activator RhaSPRO_1000068706Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei241 – 2411Interaction with sigma-70UniRule annotation
Sitei250 – 2501Interaction with sigma-70UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_04214.

Structurei

3D structure databases

ProteinModelPortaliA6TGA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107S4Z. Bacteria.
ENOG410XT8S. LUCA.
HOGENOMiHOG000290513.
KOiK02855.
OMAiIRISTNF.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TGA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILHSTDFF KAGISTVAIE PRLPQSAFPE HHHDFHEIVI VEQGSGIHVF
60 70 80 90 100
NGQPYTIGGG SVCFIRDHDR HLYEHTDNLC LTNVLYRAPD AFRFLAGVSQ
110 120 130 140 150
LLPQEQEGNY PSHWRVNQTV LQQVRHIVAQ IEAVGSDTDT HAVASREILF
160 170 180 190 200
MQLLVLLRKS SLAEEATNND ARLNQLLAWL EDHFAQEICW EEVAAQFSLS
210 220 230 240 250
LRTLHRQLKQ QTGLTPQRYL NRVRLMKARH LLRHSDESVT DIAYRCGFGD
260 270
SNHFSTLFRR EFDWSPRDIR QGRDAILQ
Length:278
Mass (Da):32,001
Last modified:August 21, 2007 - v1
Checksum:iA211EE38A8B69FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79593.1.
RefSeqiWP_002882888.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR79593; ABR79593; KPN_04214.
KEGGikpn:KPN_04214.
PATRICi20462886. VBIKlePne13394_4281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79593.1.
RefSeqiWP_002882888.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TGA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_04214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR79593; ABR79593; KPN_04214.
KEGGikpn:KPN_04214.
PATRICi20462886. VBIKlePne13394_4281.

Phylogenomic databases

eggNOGiENOG4107S4Z. Bacteria.
ENOG410XT8S. LUCA.
HOGENOMiHOG000290513.
KOiK02855.
OMAiIRISTNF.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-4251-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHAS_KLEP7
AccessioniPrimary (citable) accession number: A6TGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.