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A6TFG7

- GHRB_KLEP7

UniProt

A6TFG7 - GHRB_KLEP7

Protein

Glyoxylate/hydroxypyruvate reductase B

Gene

ghrB

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.UniRule annotation

    Catalytic activityi

    Glycolate + NADP+ = glyoxylate + NADPH.UniRule annotation
    D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei237 – 2371UniRule annotation
    Active sitei266 – 2661UniRule annotation
    Active sitei285 – 2851Proton donorUniRule annotation

    GO - Molecular functioni

    1. glyoxylate reductase (NADP) activity Source: UniProtKB-HAMAP
    2. hydroxypyruvate reductase activity Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-3952-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyoxylate/hydroxypyruvate reductase BUniRule annotation (EC:1.1.1.79UniRule annotation, EC:1.1.1.81UniRule annotation)
    Gene namesi
    Name:ghrBUniRule annotation
    Ordered Locus Names:KPN78578_38770
    ORF Names:KPN_03915
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Glyoxylate/hydroxypyruvate reductase BPRO_0000348392Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272620.KPN_03915.

    Structurei

    3D structure databases

    ProteinModelPortaliA6TFG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136700.
    KOiK00090.
    OMAiNPSAWAR.
    OrthoDBiEOG6VXFC3.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    HAMAPiMF_01667. 2_Hacid_dh_C_GhrB.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR023756. Glyo/OHPyrv_Rdtase_B.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6TFG7-1 [UniParc]FASTAAdd to Basket

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    MKPSVILYKT LPDDLLQRLE EHFSVTQVKN LRPETVSQHA EAFAQAEGLL    50
    GSSEKVDAAL LEKMPKLRAT STVSVGYDNF DVEALNARRV LLMHTPTVLT 100
    ETVADTVMAL VLSTARRVVE VAERVKAGEW TKSIGPDWFG TDVHHKTLGI 150
    VGMGRIGMAL AQRAHFGFGM PILYNARRQH PQAEERFNAR YCDLDTLLQE 200
    ADFVCLILPL SEETHHLFGQ AQFAKMKSSA IFINAGRGPV VDEQALIAAL 250
    QNGEIHAAGL DVFEHEPLAK DSPLLSLPNV VALPHIGSAT HETRYNMAAC 300
    AVDNLIDALN GNVEKNCVNP QVK 323
    Length:323
    Mass (Da):35,433
    Last modified:August 21, 2007 - v1
    Checksum:i27C85343A346EDE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR79301.1.
    RefSeqiYP_001337568.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR79301; ABR79301; KPN_03915.
    GeneIDi5341612.
    KEGGikpn:KPN_03915.
    PATRICi20462269. VBIKlePne13394_3978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR79301.1 .
    RefSeqi YP_001337568.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6TFG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_03915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR79301 ; ABR79301 ; KPN_03915 .
    GeneIDi 5341612.
    KEGGi kpn:KPN_03915.
    PATRICi 20462269. VBIKlePne13394_3978.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136700.
    KOi K00090.
    OMAi NPSAWAR.
    OrthoDBi EOG6VXFC3.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-3952-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    HAMAPi MF_01667. 2_Hacid_dh_C_GhrB.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR023756. Glyo/OHPyrv_Rdtase_B.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiGHRB_KLEP7
    AccessioniPrimary (citable) accession number: A6TFG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3