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A6TFG7 (GHRB_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glyoxylate/hydroxypyruvate reductase B

EC=1.1.1.79
EC=1.1.1.81
Gene names
Name:ghrB
Ordered Locus Names:KPN78578_38770
ORF Names:KPN_03915
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP-Rule MF_01667

Catalytic activity

Glycolate + NADP+ = glyoxylate + NADPH. HAMAP-Rule MF_01667

D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. HAMAP-Rule MF_01667

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01667

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01667.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

glyoxylate reductase (NADP) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

hydroxypyruvate reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Glyoxylate/hydroxypyruvate reductase B HAMAP-Rule MF_01667
PRO_0000348392

Sites

Active site2371 By similarity
Active site2661 By similarity
Active site2851Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
A6TFG7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 27C85343A346EDE5

FASTA32335,433
        10         20         30         40         50         60 
MKPSVILYKT LPDDLLQRLE EHFSVTQVKN LRPETVSQHA EAFAQAEGLL GSSEKVDAAL 

        70         80         90        100        110        120 
LEKMPKLRAT STVSVGYDNF DVEALNARRV LLMHTPTVLT ETVADTVMAL VLSTARRVVE 

       130        140        150        160        170        180 
VAERVKAGEW TKSIGPDWFG TDVHHKTLGI VGMGRIGMAL AQRAHFGFGM PILYNARRQH 

       190        200        210        220        230        240 
PQAEERFNAR YCDLDTLLQE ADFVCLILPL SEETHHLFGQ AQFAKMKSSA IFINAGRGPV 

       250        260        270        280        290        300 
VDEQALIAAL QNGEIHAAGL DVFEHEPLAK DSPLLSLPNV VALPHIGSAT HETRYNMAAC 

       310        320 
AVDNLIDALN GNVEKNCVNP QVK 

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR79301.1.
RefSeqYP_001337568.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6TFG7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272620.KPN_03915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR79301; ABR79301; KPN_03915.
GeneID5341612.
KEGGkpn:KPN_03915.
PATRIC20462269. VBIKlePne13394_3978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136700.
KOK00090.
OMANPSAWAR.
OrthoDBEOG6VXFC3.

Enzyme and pathway databases

BioCycKPNE272620:GKDC-3952-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
HAMAPMF_01667. 2_Hacid_dh_C_GhrB.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR023756. Glyo/OHPyrv_Rdtase_B.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGHRB_KLEP7
AccessionPrimary (citable) accession number: A6TFG7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families