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Protein

Glyoxylate/hydroxypyruvate reductase B

Gene

ghrB

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.UniRule annotation

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.UniRule annotation
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei237UniRule annotation1
Active sitei266UniRule annotation1
Active sitei285Proton donorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate/hydroxypyruvate reductase BUniRule annotation (EC:1.1.1.79UniRule annotation, EC:1.1.1.81UniRule annotation)
Gene namesi
Name:ghrBUniRule annotation
Ordered Locus Names:KPN78578_38770
ORF Names:KPN_03915
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003483921 – 323Glyoxylate/hydroxypyruvate reductase BAdd BLAST323

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03915

Structurei

3D structure databases

ProteinModelPortaliA6TFG7
SMRiA6TFG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5I Bacteria
COG1052 LUCA
HOGENOMiHOG000136700
KOiK00090
OMAiKWIAHNG

Family and domain databases

HAMAPiMF_01667 2_Hacid_dh_C_GhrB, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR023756 Glyo/OHPyrv_Rdtase_B
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

A6TFG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSVILYKT LPDDLLQRLE EHFSVTQVKN LRPETVSQHA EAFAQAEGLL
60 70 80 90 100
GSSEKVDAAL LEKMPKLRAT STVSVGYDNF DVEALNARRV LLMHTPTVLT
110 120 130 140 150
ETVADTVMAL VLSTARRVVE VAERVKAGEW TKSIGPDWFG TDVHHKTLGI
160 170 180 190 200
VGMGRIGMAL AQRAHFGFGM PILYNARRQH PQAEERFNAR YCDLDTLLQE
210 220 230 240 250
ADFVCLILPL SEETHHLFGQ AQFAKMKSSA IFINAGRGPV VDEQALIAAL
260 270 280 290 300
QNGEIHAAGL DVFEHEPLAK DSPLLSLPNV VALPHIGSAT HETRYNMAAC
310 320
AVDNLIDALN GNVEKNCVNP QVK
Length:323
Mass (Da):35,433
Last modified:August 21, 2007 - v1
Checksum:i27C85343A346EDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR79301.1
RefSeqiWP_004145219.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR79301; ABR79301; KPN_03915
KEGGikpn:KPN_03915

Similar proteinsi

Entry informationi

Entry nameiGHRB_KLEP7
AccessioniPrimary (citable) accession number: A6TFG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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