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Protein

Glyoxylate/hydroxypyruvate reductase B

Gene

ghrB

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.UniRule annotation

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.UniRule annotation
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei237 – 2371UniRule annotation
Active sitei266 – 2661UniRule annotation
Active sitei285 – 2851Proton donorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate/hydroxypyruvate reductase BUniRule annotation (EC:1.1.1.79UniRule annotation, EC:1.1.1.81UniRule annotation)
Gene namesi
Name:ghrBUniRule annotation
Ordered Locus Names:KPN78578_38770
ORF Names:KPN_03915
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Glyoxylate/hydroxypyruvate reductase BPRO_0000348392Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03915.

Structurei

3D structure databases

ProteinModelPortaliA6TFG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136700.
KOiK00090.
OMAiKSIGPDW.
OrthoDBiEOG6VXFC3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_01667. 2_Hacid_dh_C_GhrB.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR023756. Glyo/OHPyrv_Rdtase_B.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TFG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSVILYKT LPDDLLQRLE EHFSVTQVKN LRPETVSQHA EAFAQAEGLL
60 70 80 90 100
GSSEKVDAAL LEKMPKLRAT STVSVGYDNF DVEALNARRV LLMHTPTVLT
110 120 130 140 150
ETVADTVMAL VLSTARRVVE VAERVKAGEW TKSIGPDWFG TDVHHKTLGI
160 170 180 190 200
VGMGRIGMAL AQRAHFGFGM PILYNARRQH PQAEERFNAR YCDLDTLLQE
210 220 230 240 250
ADFVCLILPL SEETHHLFGQ AQFAKMKSSA IFINAGRGPV VDEQALIAAL
260 270 280 290 300
QNGEIHAAGL DVFEHEPLAK DSPLLSLPNV VALPHIGSAT HETRYNMAAC
310 320
AVDNLIDALN GNVEKNCVNP QVK
Length:323
Mass (Da):35,433
Last modified:August 21, 2007 - v1
Checksum:i27C85343A346EDE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79301.1.
RefSeqiWP_004145219.1. NC_009648.1.
YP_001337568.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR79301; ABR79301; KPN_03915.
KEGGikpn:KPN_03915.
PATRICi20462269. VBIKlePne13394_3978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR79301.1.
RefSeqiWP_004145219.1. NC_009648.1.
YP_001337568.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TFG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_03915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR79301; ABR79301; KPN_03915.
KEGGikpn:KPN_03915.
PATRICi20462269. VBIKlePne13394_3978.

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136700.
KOiK00090.
OMAiKSIGPDW.
OrthoDBiEOG6VXFC3.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3952-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_01667. 2_Hacid_dh_C_GhrB.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR023756. Glyo/OHPyrv_Rdtase_B.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiGHRB_KLEP7
AccessioniPrimary (citable) accession number: A6TFG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: May 27, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.