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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation

Enzyme regulationi

Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi853 – 872H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKPNE272620:G1G8J-4085-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:KPN78578_37510
ORF Names:KPN_03788
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857731 – 901HTH-type transcriptional regulator MalTAdd BLAST901

Interactioni

Subunit structurei

Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03788

Structurei

3D structure databases

ProteinModelPortaliA6TF41
SMRiA6TF41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini829 – 894HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MalT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR Bacteria
COG2909 LUCA
HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PF13181 TPR_8, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6TF41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLEHTVVRE RLLAKLSGAN NYRLVLITSP AGYGKTTLIS
60 70 80 90 100
QWAAGKNDLG WFSLDEGDNQ QERFASYLIA AIQQATGNHC AASEAMVQKR
110 120 130 140 150
QYASLSSLFA QLFIELADWQ RPLYLVIDDY HLINNPVIHD AMRFFLRHQP
160 170 180 190 200
ENMTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFTHQE AKQFFDCRLT
210 220 230 240 250
SPIEADDSSR LCDDVAGWAT ALQLIALSAR QNNSSAQHSA RRFAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDARTRNF LLKSSLLRSM NDALIVRVTG EENGQMQLEE
310 320 330 340 350
IERQGLFLQR MDDSGEWFRY HPLFGSFLRQ RCQWELAVEL PEIHRAAAES
360 370 380 390 400
WMAQGFPSEA IHHALAAGDA KMLRDILLNH AWGMFNHSEL GLLEQSLAAL
410 420 430 440 450
PWSNLLENPR LILLQAWLMQ SQHRYSEVNT LLARAEQEMS VEMDTAMHGD
460 470 480 490 500
FNALRAQVAI NDGDQDEAER LSMVALEELP LANYYSRIVA TSVHGEVLHC
510 520 530 540 550
KGKLTKSLAV MQQTEQMARR HDVWHYALWS IIQQSEILFA QGFLQAAWES
560 570 580 590 600
QEKAFQLVRE QHLEQLPMHE FLLRIRSQLL WAWARLDEAE ACARQGMDVL
610 620 630 640 650
STYQPQQQLQ CLALMVQCSL ARGDLDNARS HLNRLENLLG NGHYHSDWVS
660 670 680 690 700
NADKVRVIYW QMTGDKTAAA NWLRQTPKPE FANNHFLQSQ WRNIARAQIL
710 720 730 740 750
LGDFEPAEMV LEELNENARS LRLMSDLNRN LLLLNQLYWQ SGRKSEAQKA
760 770 780 790 800
LLEALTLANR TGFINHFVIE GEAMAQQLRQ LIQLNTLPEL EQHRAQRILR
810 820 830 840 850
DINQHHRHKF AHFDEGFVER LLNHPEVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL DVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):103,145
Last modified:August 21, 2007 - v1
Checksum:iDB40C8BB813B066B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR79175.1
RefSeqiWP_015959097.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR79175; ABR79175; KPN_03788
KEGGikpn:KPN_03788

Similar proteinsi

Entry informationi

Entry nameiMALT_KLEP7
AccessioniPrimary (citable) accession number: A6TF41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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