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A6TEX7

- EFTU_KLEP7

UniProt

A6TEX7 - EFTU_KLEP7

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Protein
Elongation factor Tu
Gene
tufA, KPN78578_36870, KPN_03724
tufB, KPN78578_42920, KPN_04357
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3761-MONOMER.
KPNE272620:GKDC-4394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tufA
Ordered Locus Names:KPN78578_36870
ORF Names:KPN_03724
AND
Name:tufB
Ordered Locus Names:KPN78578_42920
ORF Names:KPN_04357
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuUniRule annotation
PRO_1000015675Add
BLAST

Proteomic databases

PRIDEiA6TEX7.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_04357.

Structurei

3D structure databases

ProteinModelPortaliA6TEX7.
SMRiA6TEX7. Positions 4-394.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TEX7-1 [UniParc]FASTAAdd to Basket

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MSKEKFERTK PHVNVGTIGH VDHGKTTLTA AITTVLAKTY GGSARAFDQI    50
DNAPEEKARG ITINTSHVEY DTPTRHYAHV DCPGHADYVK NMITGAAQMD 100
GAILVVAATD GPMPQTREHI LLGRQVGVPY IIVFLNKCDM VDDEELLELV 150
EMEVRELLSQ YDFPGDDTPI VRGSALKALE GDAEWEAKII ELAGHLDTYI 200
PEPERAIDKP FLLPIEDVFS ISGRGTVVTG RVERGIIKVG EEVEIVGIKE 250
TAKTTCTGVE MFRKLLDEGR AGENVGVLLR GIKREEIERG QVLAKPGTIN 300
PHTKFESEVY ILSKDEGGRH TPFFKGYRPQ FYFRTTDVTG TIELPEGVEM 350
VMPGDNIKMV VTLIHPIAMD DGLRFAIREG GRTVGAGVVA KVLG 394
Length:394
Mass (Da):43,246
Last modified:August 21, 2007 - v1
Checksum:iDBA4133541205DD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR79111.1.
CP000647 Genomic DNA. Translation: ABR79716.1.
RefSeqiYP_001337378.1. NC_009648.1.
YP_001337983.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR79111; ABR79111; KPN_03724.
ABR79716; ABR79716; KPN_04357.
GeneIDi5338856.
5342416.
KEGGikpn:KPN_03724.
kpn:KPN_04357.
PATRICi20461877. VBIKlePne13394_3783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR79111.1 .
CP000647 Genomic DNA. Translation: ABR79716.1 .
RefSeqi YP_001337378.1. NC_009648.1.
YP_001337983.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TEX7.
SMRi A6TEX7. Positions 4-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_04357.

Proteomic databases

PRIDEi A6TEX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR79111 ; ABR79111 ; KPN_03724 .
ABR79716 ; ABR79716 ; KPN_04357 .
GeneIDi 5338856.
5342416.
KEGGi kpn:KPN_03724.
kpn:KPN_04357.
PATRICi 20461877. VBIKlePne13394_3783.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-3761-MONOMER.
KPNE272620:GKDC-4394-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiEFTU_KLEP7
AccessioniPrimary (citable) accession number: A6TEX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi