mdh

Functionⁱ

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityⁱ

(S)-malate + NAD⁺ = oxaloacetate + NADH.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	34	NADBy similarity	1
Binding siteⁱ	81	SubstrateBy similarity	1
Binding siteⁱ	87	SubstrateBy similarity	1
Binding siteⁱ	94	NADBy similarity	1
Binding siteⁱ	119	SubstrateBy similarity	1
Binding siteⁱ	153	SubstrateBy similarity	1
Active siteⁱ	177	Proton acceptorBy similarity	1
Binding siteⁱ	227	NADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	7 – 13	NADBy similarity		7
Nucleotide bindingⁱ	117 – 119	NADBy similarity		3

GO - Molecular functionⁱ

L-malate dehydrogenase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
malate metabolic process Source: InterPro
tricarboxylic acid cycle Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Tricarboxylic acid cycle
Ligand	NAD

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Malate dehydrogenase (EC:1.1.1.37)
Gene namesⁱ	Name:mdh Ordered Locus Names:KPN78578_36130 ORF Names:KPN_03644
Organismⁱ	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifierⁱ	272620 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Klebsiella pneumoniae subsp. pneumoniae
Proteomesⁱ	UP000000265 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313532	1 – 312	Malate dehydrogenaseAdd BLAST		312

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	272620.KPN_03644

STRINGⁱ

272620.KPN_03644

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6TEQ3
SMRⁱ	A6TEQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105C80 Bacteria COG0039 LUCA
HOGENOMⁱ	HOG000213792
KEGG Orthology (KO) More...KOⁱ	K00024
OMAⁱ	QCTPKVE

Family and domain databases

Gene3Dⁱ	3.90.110.101 hit
HAMAPⁱ	MF_01516 Malate_dehydrog_1, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR001252 Malate_DH_AS IPR010097 Malate_DH_type1 IPR023958 Malate_DH_type1_bac IPR036291 NAD(P)-bd_dom_sf
PANTHERⁱ	PTHR11540:SF22 PTHR11540:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01772 MDH_euk_gproteo, 1 hit
PROSITEⁱ	View protein in PROSITE PS00068 MDH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A6TEQ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKVAVLGAAG GIGQALALLL KTQLPSGSEL SLYDIAPVTP GVAVDLSHIP 
        60         70         80         90        100
TDVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL FNVNAGIVKN 
       110        120        130        140        150
LVQQIAKTCP QACIGIITNP VNTTVAIAAE VLKKAGVYDK NKLFGVTTLD 
       160        170        180        190        200
IIRSNTFVAE LKGKSATEVE VPVIGGHSGV TILPLLSQIP GVSFSDQEIA 
       210        220        230        240        250
DLTKRIQNAG TEVVEAKAGG GSATLSMGQA AARFGLSLVR AMQGEKGVVE 
       260        270        280        290        300
CAYVEGDGHY ARFFSQPLLL GKNGVEERQS IGKLSAFEQQ ALEGMLDTLK 
       310 
KDIALGEDFV NK

Length:312

Mass (Da):32,426

Last modified:August 21, 2007 - v1

Checksum:ⁱB33508066CD1FCFB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000647 Genomic DNA Translation: ABR79037.1 AJ635379 Genomic DNA Translation: CAG25790.1
NCBI Reference Sequences More...RefSeqⁱ	WP_002918570.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaⁱ	ABR79037; ABR79037; KPN_03644
KEGGⁱ	kpn:KPN_03644

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6TEQ3	W1AY46 W9BBE4 A0A1Y0PU91 A0A0H3GWA1 V0AJA1 A0A0E1C8C6 J2E0X9 W1HJ56 A0A0J2JSX3 W8UBP4 +24	Klebsiella pneumoniae IS22 Klebsiella pneumoniae Klebsiella pneumoniae subsp. pneumoniae Klebsiella pneumoniae subsp. pneumoniae (strain HS11286) Klebsiella pneumoniae 909957 Klebsiella pneumoniae 30660/NJST258_1 Klebsiella pneumoniae subsp. pneumoniae DSM 30104 Escherichia coli ISC56 Klebsiella oxytoca Klebsiella pneumoniae 30684/NJST258_2 And more	312	UniRef100_A6TEQ3	Cluster: Malate dehydrogenase	35

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6TEQ3	A4WF48 A0A2A7PVW9 S3JL63 UPI0003A8BDAA A0A2J5PPR3 C6CJR4 A5JMX5 A0A0A8F8I7 A0A2K9QAV5 D0EVC3 +857	Enterobacter sp. (strain 638) Lelliottia amnigena (Enterobacter amnigenus) Cedecea davisae DSM 4568 Cedecea davisae Klebsiella pneumoniae Dickeya chrysanthemi (strain Ech1591) (Dickeya zeae (strain Ech1591)) Dickeya zeae EC1 Dickeya zeae Dickeya sp. CITA_B1 Dickeya sp. ICMP 9288 And more	312	UniRef90_A4WF48	Cluster: Malate dehydrogenase	868

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6TEQ3	Q42686 A8JHU0 A0A2K3D1P1 A0A150GIX3 G5BG62 UPI00062AC490 UPI00053CDA36 UPI000670FDAE E1BVT3 A0A1L1RNR3 +998	Chlamydomonas reinhardtii (Chlamydomonas smithii) Gonium pectorale (Green alga) Heterocephalus glaber (Naked mole rat) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Haliaeetus leucocephalus (Bald eagle) Anser cygnoides domesticus Gallus gallus (Chicken) Callipepla squamata (Scaled quail) Cuculus canorus (common cuckoo) Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor) And more	373	UniRef50_Q42686	Cluster: Malate dehydrogenase, mitochondrial	1,009

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000647 Genomic DNA Translation: ABR79037.1 AJ635379 Genomic DNA Translation: CAG25790.1
NCBI Reference Sequences More...RefSeqⁱ	WP_002918570.1, NC_009648.1

3D structure databases

ProteinModelPortalⁱ	A6TEQ3
SMRⁱ	A6TEQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	272620.KPN_03644

STRINGⁱ

272620.KPN_03644

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABR79037; ABR79037; KPN_03644
KEGGⁱ	kpn:KPN_03644

Phylogenomic databases

eggNOGⁱ	ENOG4105C80 Bacteria COG0039 LUCA
HOGENOMⁱ	HOG000213792
KEGG Orthology (KO) More...KOⁱ	K00024
OMAⁱ	QCTPKVE

Family and domain databases

Gene3Dⁱ	3.90.110.101 hit
HAMAPⁱ	MF_01516 Malate_dehydrog_1, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR001252 Malate_DH_AS IPR010097 Malate_DH_type1 IPR023958 Malate_DH_type1_bac IPR036291 NAD(P)-bd_dom_sf
PANTHERⁱ	PTHR11540:SF22 PTHR11540:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01772 MDH_euk_gproteo, 1 hit
PROSITEⁱ	View protein in PROSITE PS00068 MDH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MDH_KLEP7
Accessionⁱ	A6TEQ3Primary (citable) accession number: A6TEQ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	August 21, 2007
	Last modified:	March 28, 2018
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - A6TEQ3 (MDH_KLEP7)

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Malate dehydrogenase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6TEQ3 (MDH_KLEP7)

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Malate dehydrogenase

mdh

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ