UniProtKB - A6TEQ3 (MDH_KLEP7)
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Protein
Malate dehydrogenase
Gene
mdh
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Functioni
Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity
Catalytic activityi
(S)-malate + NAD+ = oxaloacetate + NADH.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 34 | NADBy similarity | 1 | |
Binding sitei | 81 | SubstrateBy similarity | 1 | |
Binding sitei | 87 | SubstrateBy similarity | 1 | |
Binding sitei | 94 | NADBy similarity | 1 | |
Binding sitei | 119 | SubstrateBy similarity | 1 | |
Binding sitei | 153 | SubstrateBy similarity | 1 | |
Active sitei | 177 | Proton acceptorBy similarity | 1 | |
Binding sitei | 227 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 7 – 13 | NADBy similarity | 7 | |
Nucleotide bindingi | 117 – 119 | NADBy similarity | 3 |
GO - Molecular functioni
- L-malate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- malate metabolic process Source: InterPro
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tricarboxylic acid cycle |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mdh Ordered Locus Names:KPN78578_36130 ORF Names:KPN_03644 |
Organismi | Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) |
Taxonomic identifieri | 272620 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Klebsiella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313532 | 1 – 312 | Malate dehydrogenaseAdd BLAST | 312 |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
STRINGi | 272620.KPN_03644 |
Structurei
3D structure databases
ProteinModelPortali | A6TEQ3 |
SMRi | A6TEQ3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105C80 Bacteria COG0039 LUCA |
HOGENOMi | HOG000213792 |
KOi | K00024 |
OMAi | QCTPKVE |
Family and domain databases
Gene3Di | 3.90.110.101 hit |
HAMAPi | MF_01516 Malate_dehydrog_1, 1 hit |
InterProi | View protein in InterPro IPR001557 L-lactate/malate_DH IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR001252 Malate_DH_AS IPR010097 Malate_DH_type1 IPR023958 Malate_DH_type1_bac IPR036291 NAD(P)-bd_dom_sf |
PANTHERi | PTHR11540:SF22 PTHR11540:SF22, 1 hit |
Pfami | View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102 Lac_mal_DH, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit |
TIGRFAMsi | TIGR01772 MDH_euk_gproteo, 1 hit |
PROSITEi | View protein in PROSITE PS00068 MDH, 1 hit |
i Sequence
Sequence statusi: Complete.
A6TEQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVAVLGAAG GIGQALALLL KTQLPSGSEL SLYDIAPVTP GVAVDLSHIP
60 70 80 90 100
TDVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL FNVNAGIVKN
110 120 130 140 150
LVQQIAKTCP QACIGIITNP VNTTVAIAAE VLKKAGVYDK NKLFGVTTLD
160 170 180 190 200
IIRSNTFVAE LKGKSATEVE VPVIGGHSGV TILPLLSQIP GVSFSDQEIA
210 220 230 240 250
DLTKRIQNAG TEVVEAKAGG GSATLSMGQA AARFGLSLVR AMQGEKGVVE
260 270 280 290 300
CAYVEGDGHY ARFFSQPLLL GKNGVEERQS IGKLSAFEQQ ALEGMLDTLK
310
KDIALGEDFV NK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000647 Genomic DNA Translation: ABR79037.1 AJ635379 Genomic DNA Translation: CAG25790.1 |
RefSeqi | WP_002918570.1, NC_009648.1 |
Genome annotation databases
EnsemblBacteriai | ABR79037; ABR79037; KPN_03644 |
KEGGi | kpn:KPN_03644 |
Similar proteinsi
Entry informationi
Entry namei | MDH_KLEP7 | |
Accessioni | A6TEQ3Primary (citable) accession number: A6TEQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | August 21, 2007 | |
Last modified: | March 28, 2018 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |