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Protein

Modulator protein MzrA

Gene

mzrA

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.UniRule annotation

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator protein MzrAUniRule annotation
Gene namesi
Name:mzrAUniRule annotation
Ordered Locus Names:KPN78578_34950
ORF Names:KPN_03524
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicUniRule annotationAdd
BLAST
Transmembranei12 – 3221HelicalUniRule annotationAdd
BLAST
Topological domaini33 – 12896PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Modulator protein MzrAPRO_0000413189Add
BLAST

Interactioni

Subunit structurei

Interacts with EnvZ.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03524.

Structurei

Secondary structure

1
128
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 459Combined sources
Helixi53 – 6210Combined sources
Beta strandi68 – 736Combined sources
Beta strandi76 – 838Combined sources
Helixi84 – 9714Combined sources
Beta strandi100 – 1078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4PWUX-ray2.45A/B/C/D32-128[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MzrA family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VD9. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVMKRPSLR QFSWLLGGSL LLGALFWLWL AVQQQEATLA IRPVGQGIGM
60 70 80 90 100
PDGFSVWHHL DANGIRFKSI TPQKDGLLIK FDSTAQGAAA KEVLGRALPH
110 120
GYIIALLEDD NSPTAWLSRL RDAPHRLG
Length:128
Mass (Da):14,127
Last modified:August 21, 2007 - v1
Checksum:i13B3FCFAD25F2EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78919.1.

Genome annotation databases

EnsemblBacteriaiABR78919; ABR78919; KPN_03524.
KEGGikpn:KPN_03524.
PATRICi20461469. VBIKlePne13394_3586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78919.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4PWUX-ray2.45A/B/C/D32-128[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_03524.

Protocols and materials databases

DNASUi5341542.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR78919; ABR78919; KPN_03524.
KEGGikpn:KPN_03524.
PATRICi20461469. VBIKlePne13394_3586.

Phylogenomic databases

eggNOGiENOG4105VD9. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3561-MONOMER.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMZRA_KLEP7
AccessioniPrimary (citable) accession number: A6TED5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.