Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modulator protein MzrA

Gene

mzrA

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.UniRule annotation

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator protein MzrAUniRule annotation
Gene namesi
Name:mzrAUniRule annotation
Ordered Locus Names:KPN78578_34950
ORF Names:KPN_03524
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicUniRule annotationAdd BLAST11
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Topological domaini33 – 128PeriplasmicUniRule annotationAdd BLAST96

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004131891 – 128Modulator protein MzrAAdd BLAST128

Interactioni

Subunit structurei

Interacts with EnvZ.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03524.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 45Combined sources9
Helixi53 – 62Combined sources10
Beta strandi68 – 73Combined sources6
Beta strandi76 – 83Combined sources8
Helixi84 – 97Combined sources14
Beta strandi100 – 107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PWUX-ray2.45A/B/C/D32-128[»]
SMRiA6TED5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MzrA family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VD9. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVMKRPSLR QFSWLLGGSL LLGALFWLWL AVQQQEATLA IRPVGQGIGM
60 70 80 90 100
PDGFSVWHHL DANGIRFKSI TPQKDGLLIK FDSTAQGAAA KEVLGRALPH
110 120
GYIIALLEDD NSPTAWLSRL RDAPHRLG
Length:128
Mass (Da):14,127
Last modified:August 21, 2007 - v1
Checksum:i13B3FCFAD25F2EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78919.1.

Genome annotation databases

EnsemblBacteriaiABR78919; ABR78919; KPN_03524.
KEGGikpn:KPN_03524.
PATRICi20461469. VBIKlePne13394_3586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78919.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PWUX-ray2.45A/B/C/D32-128[»]
SMRiA6TED5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_03524.

Protocols and materials databases

DNASUi5341542.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR78919; ABR78919; KPN_03524.
KEGGikpn:KPN_03524.
PATRICi20461469. VBIKlePne13394_3586.

Phylogenomic databases

eggNOGiENOG4105VD9. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMZRA_KLEP7
AccessioniPrimary (citable) accession number: A6TED5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.