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A6TEC2 (RLMG_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174
Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG
Gene names
Name:rlmG
Ordered Locus Names:KPN78578_34820
ORF Names:KPN_03511
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859

Catalytic activity

S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859

Subcellular location

Cytoplasm Potential HAMAP MF_01859.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

rRNA (guanine-N2-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859
PRO_0000366467

Sequences

Sequence LengthMass (Da)Tools
A6TEC2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: F703B287F090F71B

FASTA37641,915
        10         20         30         40         50         60 
MSQAELNGEL FTLERFPPNA EEEALQAWEA ADEYLLQQVN DVDGLTLIFN DGFGALACAL 

        70         80         90        100        110        120 
AERNPVSIND SFISELATRH NLRMNGIDEE SVRFQDSLSP LPAAPALVLI KVPKQLALLE 

       130        140        150        160        170        180 
QQLRALREVV TPETRIIAAA KARDVHNSTL ALFEKILGTT TTSLAWKKAR LIHCVFTAPE 

       190        200        210        220        230        240 
LADAPQTYSW KLDGTPWTIH NHANVFARSG LDIGARFFLQ HLPSDLEGEI ADLGCGNGVI 

       250        260        270        280        290        300 
GLQALAQNPN ARVMFTDESH MAVASSRLNV ERNLPDDIAR CEFMVNNSLS GIEPDRFTAI 

       310        320        330        340        350        360 
LCNPPFHQQH AITDHIAWQM FNDARRSLKY GGELYVVGNR HLDYFRKLKR AFGNCTTIAT 

       370 
NNKFVILKAT KVRKQR

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000647 Genomic DNA. Translation: ABR78906.1.
RefSeqYP_001337173.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6TEC2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TEC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5341443.
GenomeReviewsGene locus KPN78578_34820 in contig CP000647_GR.
KEGGkpn:KPN_03511.
PATRIC20461443. VBIKlePne13394_3573.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2813.
HOGENOMHBG321931.
OMANRHLGYH.
ProtClustDBCLSK2505749.

Family and domain databases

HAMAPMF_01859. 23SrRNA_methyltr_G.
[Tree]
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR007848. Small_mtfrase.
[Graphical view]
KOK11391.
PfamPF05175. MTS. 1 hit.
[Graphical view]
PIRSFPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMG_KLEP7
AccessionPrimary (citable) accession number: A6TEC2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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