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Protein

Ribosomal RNA large subunit methyltransferase G

Gene

rlmG

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase GUniRule annotation (EC:2.1.1.174UniRule annotation)
Alternative name(s):
23S rRNA m2G1835 methyltransferaseUniRule annotation
rRNA (guanine-N(2)-)-methyltransferase RlmGUniRule annotation
Gene namesi
Name:rlmGUniRule annotation
Ordered Locus Names:KPN78578_34820
ORF Names:KPN_03511
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Ribosomal RNA large subunit methyltransferase GPRO_0000366467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_03511.

Structurei

3D structure databases

ProteinModelPortaliA6TEC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8J. Bacteria.
COG2813. LUCA.
HOGENOMiHOG000246323.
KOiK11391.
OMAiFHQQQVV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01859. 23SrRNA_methyltr_G. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A6TEC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAELNGEL FTLERFPPNA EEEALQAWEA ADEYLLQQVN DVDGLTLIFN
60 70 80 90 100
DGFGALACAL AERNPVSIND SFISELATRH NLRMNGIDEE SVRFQDSLSP
110 120 130 140 150
LPAAPALVLI KVPKQLALLE QQLRALREVV TPETRIIAAA KARDVHNSTL
160 170 180 190 200
ALFEKILGTT TTSLAWKKAR LIHCVFTAPE LADAPQTYSW KLDGTPWTIH
210 220 230 240 250
NHANVFARSG LDIGARFFLQ HLPSDLEGEI ADLGCGNGVI GLQALAQNPN
260 270 280 290 300
ARVMFTDESH MAVASSRLNV ERNLPDDIAR CEFMVNNSLS GIEPDRFTAI
310 320 330 340 350
LCNPPFHQQH AITDHIAWQM FNDARRSLKY GGELYVVGNR HLDYFRKLKR
360 370
AFGNCTTIAT NNKFVILKAT KVRKQR
Length:376
Mass (Da):41,915
Last modified:August 21, 2007 - v1
Checksum:iF703B287F090F71B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78906.1.
RefSeqiWP_002917887.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR78906; ABR78906; KPN_03511.
KEGGikpn:KPN_03511.
PATRICi20461443. VBIKlePne13394_3573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78906.1.
RefSeqiWP_002917887.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TEC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_03511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR78906; ABR78906; KPN_03511.
KEGGikpn:KPN_03511.
PATRICi20461443. VBIKlePne13394_3573.

Phylogenomic databases

eggNOGiENOG4105D8J. Bacteria.
COG2813. LUCA.
HOGENOMiHOG000246323.
KOiK11391.
OMAiFHQQQVV.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3548-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01859. 23SrRNA_methyltr_G. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMG_KLEP7
AccessioniPrimary (citable) accession number: A6TEC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.