Reviewed, UniProtKB/Swiss-Prot A6TEC2 (RLMG_KLEP7)

Names and origin

Protein names

Recommended name:
    Ribosomal RNA large subunit methyltransferase G
    EC=2.1.1.52
Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase rlmG
    23S rRNA m2G1835 methyltransferase

Gene names

Name:	rlmG
Ordered Locus Names:	KPN78578_34820
ORF Names:	KPN_03511

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity.
Catalytic activity	S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(2)-methylguanine. HAMAP MF_01859
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA methylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859		PRO_0000366467

Sequences

	Sequence		Length	Mass (Da)
	A6TEC2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: F703B287F090F71B	FASTA	376	41,915
	10 20 30 40 50 60 MSQAELNGEL FTLERFPPNA EEEALQAWEA ADEYLLQQVN DVDGLTLIFN DGFGALACAL 70 80 90 100 110 120 AERNPVSIND SFISELATRH NLRMNGIDEE SVRFQDSLSP LPAAPALVLI KVPKQLALLE 130 140 150 160 170 180 QQLRALREVV TPETRIIAAA KARDVHNSTL ALFEKILGTT TTSLAWKKAR LIHCVFTAPE 190 200 210 220 230 240 LADAPQTYSW KLDGTPWTIH NHANVFARSG LDIGARFFLQ HLPSDLEGEI ADLGCGNGVI 250 260 270 280 290 300 GLQALAQNPN ARVMFTDESH MAVASSRLNV ERNLPDDIAR CEFMVNNSLS GIEPDRFTAI 310 320 330 340 350 360 LCNPPFHQQH AITDHIAWQM FNDARRSLKY GGELYVVGNR HLDYFRKLKR AFGNCTTIAT 370 NNKFVILKAT KVRKQR

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000647 Genomic DNA. Translation: ABR78906.1.
RefSeq	YP_001337173.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TEC2.
Genome annotation databases
GeneID	5341443.
GenomeReviews	Gene locus KPN78578_34820 in contig CP000647_GR.
KEGG	kpn:KPN_03511.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NRHLGYH.
Family and domain databases
HAMAP	MF_01859. [Tree]
InterPro	IPR017237. rRNA_m2G-MeTrfase_RsmD. IPR007848. Small_mtfrase. [Graphical view]
Pfam	PF05175. MTS. 1 hit. [Graphical view]
PIRSF	PIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMG_KLEP7

Accession

Primary (citable) accession number: A6TEC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)