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A6TDR5 (GCSP_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:KPN78578_32750
ORF Names:KPN_03339
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045586

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6TDR5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 20AE60CF45FFCB3E

FASTA957104,553
        10         20         30         40         50         60 
MTQTLSQLEN RDAFIERHIG PDAQQQQEML KTVGADSLNA LIGQIVPQDI QLATPPQVGD 

        70         80         90        100        110        120 
ATTEFAALAE LKAIASRNKR FKSYIGMGYT AVQLPPVIQR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLESLLNF QQVTLDLTGL DIASASLLDE ATAAAEAMAM AKRVSKLKSA NRFFVAADVH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFDVIV DDADKVLDHQ DVFGVLLQQV GTTGEIHDYS KLIAELKARK 

       250        260        270        280        290        300 
VIVSVAADFM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAK DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV FHGPAGLKRI 

       370        380        390        400        410        420 
AGRIHRLTDI LADGLQKKGL KLRHAHYFDT LCVEVADKAA VLARAEALQI NLRSDIHGAV 

       430        440        450        460        470        480 
GITLDEATTR EDVLNLFRAI VGDDHGLDID TLDKDVALDS RSIPAAMLRD DAILTHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YMHALERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPVE 

       550        560        570        580        590        600 
QAEGYQQMIA QLSDWLVKLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMQVV VVACDKNGNI DLADLREKAE QAGANLSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCEI VHQFGGQVYL DGANMNAQVG ITSPGFIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGSIGVKAHL APFVPGHSVV QIEGMLTRQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 

       790        800        810        820        830        840 
ASQNAILNAN YIATRLKDAY PVLYTGRDGR VAHECILDIR PLKEETGISE LDIAKRLIDF 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIDRVKAGEW PLEDNPLVNA 

       910        920        930        940        950 
PHTQGELVGE WNHPYSRELA VFPAGLHNKY WPTVKRLDDV YGDRNLFCSC VPMSEYQ 

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR78736.1.
RefSeqYP_001336966.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6TDR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272620.KPN_03339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR78736; ABR78736; KPN_03339.
GeneID5342745.
KEGGkpn:KPN_03339.
PATRIC20461014. VBIKlePne13394_3361.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycKPNE272620:GKDC-3339-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_KLEP7
AccessionPrimary (citable) accession number: A6TDR5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families