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A6TD83

- FUCI_KLEP7

UniProt

A6TD83 - FUCI_KLEP7

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Protein

L-fucose isomerase

Gene

fucI

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 3371Proton acceptorUniRule annotation
Metal bindingi337 – 3371ManganeseUniRule annotation
Active sitei361 – 3611Proton acceptorUniRule annotation
Metal bindingi361 – 3611ManganeseUniRule annotation
Metal bindingi528 – 5281ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-3153-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:KPN78578_30930
ORF Names:KPN_03153
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591L-fucose isomerasePRO_1000067222Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_03153.

Structurei

3D structure databases

ProteinModelPortaliA6TD83.
SMRiA6TD83. Positions 1-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiKEGQDYR.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

A6TD83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKISLPKIG IRPVIDGRRM GVRESLEAQT MNMAKATAAL ISEKLRHACG
60 70 80 90 100
ARVECVIADT CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD
110 120 130 140 150
PLRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS
160 170 180 190 200
IPADVEEKLL RFARAGLAVA SMKGKSYLSL GGVSMGIAGS IVDHNFFESW
210 220 230 240 250
LGMKVQAVDM TELRRRIDQK IYDETELEMA LAWADKHFRY GEDQNAEQYK
260 270 280 290 300
RNETQSRAVL KESLLMAMCI RDMMQGNPKL AEKGLVEESL GYNAIAAGFQ
310 320 330 340 350
GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLMGH
360 370 380 390 400
QLTGTAQVFA DVRTYWSPDA VERVTGQPLT GRAEHGIIHL INSGSAALDG
410 420 430 440 450
SCQQRDAQGN PTMKPHWEIE QSEADACLAA TEWCPAIHEY FRGGGFSSRF
460 470 480 490 500
LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VALPKAMHDQ LDARTNSTWP
510 520 530 540 550
TTWFAPRLTG KGPFSDVYSV MANWGANHGV LTIGHVGADF ITLAAMLRIP
560 570 580 590
VCMHNVEEAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R
Length:591
Mass (Da):64,768
Last modified:August 21, 2007 - v1
Checksum:i3FE3FF01B23AB3D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR78554.1.
RefSeqiYP_001336784.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR78554; ABR78554; KPN_03153.
GeneIDi5341469.
KEGGikpn:KPN_03153.
PATRICi20460630. VBIKlePne13394_3173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR78554.1 .
RefSeqi YP_001336784.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TD83.
SMRi A6TD83. Positions 1-591.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_03153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR78554 ; ABR78554 ; KPN_03153 .
GeneIDi 5341469.
KEGGi kpn:KPN_03153.
PATRICi 20460630. VBIKlePne13394_3173.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000249674.
KOi K01818.
OMAi KEGQDYR.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci KPNE272620:GKDC-3153-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiFUCI_KLEP7
AccessioniPrimary (citable) accession number: A6TD83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3