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Protein

GDP-mannose pyrophosphatase NudK

Gene

nudK

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of GDP-mannose.By similarity

Catalytic activityi

GDP-mannose + H2O = GMP + mannose-1-phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose pyrophosphatase NudK (EC:3.6.1.-)
Gene namesi
Name:nudK
Ordered Locus Names:KPN78578_27500
ORF Names:KPN_02801
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198GDP-mannose pyrophosphatase NudKPRO_0000342492Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272620.KPN_02801.

Structurei

3D structure databases

ProteinModelPortaliA6TC90.
SMRiA6TC90. Positions 5-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 180138Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi86 – 10621Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudK subfamily.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107VIJ. Bacteria.
ENOG410YMTX. LUCA.
HOGENOMiHOG000045855.
KOiK12945.
OMAiELIHFFA.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TC90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNIHVIKD KILSENWFVL RNMTYELTRA DGSVVRHKRE VYDRGNGATV
60 70 80 90 100
LLYNRHKQTV VLVRQFRVAT WVNGNHDGML IETCAGLLDN DEPEACIRKE
110 120 130 140 150
AVEETGYEVG EVRKLFELFM SPGGVTEVVH FFIAEYSDAQ RTTSGGGVDD
160 170 180 190
EAIEVLELPF SQALQMVADG EIRDGKAVIL LQYLQTSGLM SGNSDKSD
Length:198
Mass (Da):22,157
Last modified:August 21, 2007 - v1
Checksum:iF0741E6E226EF800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78211.1.
RefSeqiWP_002913754.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR78211; ABR78211; KPN_02801.
KEGGikpn:KPN_02801.
PATRICi20459904. VBIKlePne13394_2819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78211.1.
RefSeqiWP_002913754.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TC90.
SMRiA6TC90. Positions 5-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_02801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR78211; ABR78211; KPN_02801.
KEGGikpn:KPN_02801.
PATRICi20459904. VBIKlePne13394_2819.

Phylogenomic databases

eggNOGiENOG4107VIJ. Bacteria.
ENOG410YMTX. LUCA.
HOGENOMiHOG000045855.
KOiK12945.
OMAiELIHFFA.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2801-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDK_KLEP7
AccessioniPrimary (citable) accession number: A6TC90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.