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Protein

Cysteine synthase

Gene

cysK

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei273Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported, TransferaseUniRule annotation
Biological processAmino-acid biosynthesis, Cysteine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine synthaseUniRule annotation (EC:2.5.1.47UniRule annotation)
Gene namesi
Name:cysKImported
ORF Names:KPN_02761Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)Imported
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_02761

Structurei

3D structure databases

ProteinModelPortaliA6TC50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 300PALPInterPro annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni177 – 181Pyridoxal phosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6T Bacteria
COG0031 LUCA
HOGENOMiHOG000217394
KOiK01738
OMAiWDSGERY

Family and domain databases

InterProiView protein in InterPro
IPR005856 Cys_synth
IPR005859 CysK
IPR001216 P-phosphate_BS
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01139 cysK, 1 hit
TIGR01136 cysKM, 1 hit
PROSITEiView protein in PROSITE
PS00901 CYS_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6TC50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIFEDNSL TIGHTPLVRL NRIGNGRILA KVESRNPSFS VKCRIGANMI
60 70 80 90 100
WDAEKRGVLK PGVELVEPTS GNTGIALAYV AAARGYKLTL TMPETMSIER
110 120 130 140 150
RKLLKALGAN LVLTEGAKGM KGAIQKAEEI VASNPEQFLL LQQFSNPANP
160 170 180 190 200
EIHEKTTGPE IWEDTDGQVD VFISGVGTGG TLTGVSRYIK NTKGKKDLIT
210 220 230 240 250
VAVEPTDSPV IAQALAGEEL KPGPHKIQGI GAGFIPGNLD LKLVDKVIGI
260 270 280 290 300
TNEEAISTAR RLMEEEGILA GISSGAAVAA ALKLQEDEAF TNKNIVVILP
310 320
SSGERYLSTA LFADLFTEKE LQQ
Length:323
Mass (Da):34,558
Last modified:August 21, 2007 - v1
Checksum:i66245EAB1E2A37A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR78171.1
RefSeqiWP_002913498.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR78171; ABR78171; KPN_02761
KEGGikpn:KPN_02761

Similar proteinsi

Entry informationi

Entry nameiA6TC50_KLEP7
AccessioniPrimary (citable) accession number: A6TC50
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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