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Protein

Cysteine synthase

Gene

cysK

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. cysteine synthase activity Source: UniProtKB-EC
  2. hydrolase activity Source: UniProtKB-KW
  3. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. cysteine biosynthetic process from serine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported, TransferaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2761-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine synthaseUniRule annotation (EC:2.5.1.47UniRule annotation)
Gene namesi
Name:cysKImported
ORF Names:KPN_02761Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)Imported
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_02761.

Structurei

3D structure databases

ProteinModelPortaliA6TC50.
SMRiA6TC50. Positions 2-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0031.
HOGENOMiHOG000217394.
KOiK01738.
OMAiVKCRIGS.
OrthoDBiEOG6Q2SP8.

Family and domain databases

InterProiIPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01139. cysK. 1 hit.
TIGR01136. cysKM. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TC50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIFEDNSL TIGHTPLVRL NRIGNGRILA KVESRNPSFS VKCRIGANMI
60 70 80 90 100
WDAEKRGVLK PGVELVEPTS GNTGIALAYV AAARGYKLTL TMPETMSIER
110 120 130 140 150
RKLLKALGAN LVLTEGAKGM KGAIQKAEEI VASNPEQFLL LQQFSNPANP
160 170 180 190 200
EIHEKTTGPE IWEDTDGQVD VFISGVGTGG TLTGVSRYIK NTKGKKDLIT
210 220 230 240 250
VAVEPTDSPV IAQALAGEEL KPGPHKIQGI GAGFIPGNLD LKLVDKVIGI
260 270 280 290 300
TNEEAISTAR RLMEEEGILA GISSGAAVAA ALKLQEDEAF TNKNIVVILP
310 320
SSGERYLSTA LFADLFTEKE LQQ
Length:323
Mass (Da):34,558
Last modified:August 21, 2007 - v1
Checksum:i66245EAB1E2A37A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78171.1.
RefSeqiYP_001336401.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR78171; ABR78171; KPN_02761.
GeneIDi5342507.
KEGGikpn:KPN_02761.
PATRICi20459822. VBIKlePne13394_2778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78171.1.
RefSeqiYP_001336401.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6TC50.
SMRiA6TC50. Positions 2-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_02761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR78171; ABR78171; KPN_02761.
GeneIDi5342507.
KEGGikpn:KPN_02761.
PATRICi20459822. VBIKlePne13394_2778.

Phylogenomic databases

eggNOGiCOG0031.
HOGENOMiHOG000217394.
KOiK01738.
OMAiVKCRIGS.
OrthoDBiEOG6Q2SP8.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2761-MONOMER.

Family and domain databases

InterProiIPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01139. cysK. 1 hit.
TIGR01136. cysKM. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578Imported.

Entry informationi

Entry nameiA6TC50_KLEP7
AccessioniPrimary (citable) accession number: A6TC50
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.