A6TC33 (GLK_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	KPN78578_26930
ORF Names:	KPN_02738

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Klebsiella pneumoniae subsp. pneumoniae

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Glucokinase HAMAP-Rule MF_00524		PRO_1000050970
Regions
	Nucleotide binding	8 – 13	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A6TC33 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 73F82D688259986D	FASTA	321	34,422
	10 20 30 40 50 60 MTKFALVGDV GGTNARLALC DLASGEISRA KTYSGLDYPS LEAVVRVYLE EHQVTVNEGC 70 80 90 100 110 120 IAIACPITGD WVAMTNHTWA FSIAEMKRNL GFAHLEIIND FTAVSMAIPM LKAEHLIQFG 130 140 150 160 170 180 GSAPVAGKPI AVYGAGTGLG VAHLVHVDKR WVSLPGEGGH VDFAPNSEEE GIILEELRAE 190 200 210 220 230 240 LGHVSAERVL SGPGLVNLYR AIVKSDGRLP ENLQPREVTE RALADSCTDC RRALSLFCVI 250 260 270 280 290 300 MGRFGGNLAL TLGTFGGVYI AGGIVPRFLE FFKASGFRGG FEDKGRFKAY VQDIPVYLIV 310 320 HDNPGLLGSG AHLRQTLGQV L

References

[1]

The Klebsiella pneumonia Genome Sequencing Project McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR78154.1.
RefSeq	YP_001336384.1. NC_009648.1.
3D structure databases
ProteinModelPortal	A6TC33.
SMR	A6TC33. Positions 2-321.
ModBase	Search...
Protein-protein interaction databases
STRING	272620.KPN_02738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR78154; ABR78154; KPN_02738.
GeneID	5338195.
KEGG	kpn:KPN_02738.
PATRIC	20459776. VBIKlePne13394_2761.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	FADKGCM.
ProtClustDB	PRK00292.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_KLEP7

Accession

Primary (citable) accession number: A6TC33

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program