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A6TBU8

- RHMD_KLEP7

UniProt

A6TBU8 - RHMD_KLEP7

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Protein

L-rhamnonate dehydratase

Gene

rhmD

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).UniRule annotation

Catalytic activityi

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291SubstrateUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi222 – 2221MagnesiumUniRule annotation
Metal bindingi248 – 2481MagnesiumUniRule annotation
Metal bindingi276 – 2761MagnesiumUniRule annotation
Sitei298 – 2981Increases basicity of active site HisUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Binding sitei345 – 3451SubstrateUniRule annotation
Sitei345 – 3451Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. L-rhamnonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnonate dehydrataseUniRule annotation (EC:4.2.1.90UniRule annotation)
Short name:
RhamDUniRule annotation
Gene namesi
Name:rhmDUniRule annotation
Ordered Locus Names:KPN78578_26080
ORF Names:KPN_02652
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401L-rhamnonate dehydratasePRO_0000351700Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_02652.

Structurei

3D structure databases

ProteinModelPortaliA6TBU8.
SMRiA6TBU8. Positions 1-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4948.
HOGENOMiHOG000113755.
KOiK12661.
OMAiFCVELEA.
OrthoDBiEOG68Q0M0.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01288. Rhamnon_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TBU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLPKIKHVR AWFIGGATAE QGAGGGDYHD QGANHWIDDH IATPMSKYKQ
60 70 80 90 100
YEQSRQSFGI NVLGTLIVEV EADNGQTGFA VSTAGEMGCF IVEKHLNRFI
110 120 130 140 150
EGKCVSDIKL IHDQMLNATL YYAGSGGLVM NTISCVDLAL WDLFGKVVGL
160 170 180 190 200
PVYKLLGGAV RDEIQFYATG ARPDLAQEMG FIGGKMPTHW GPHDGDAGIR
210 220 230 240 250
KDVAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PYNLKWIEEC
260 270 280 290 300
LPPQQYEGYR ELKRQAPAGM MVTSGEHHGT LQSFRTLSET GIDIMQPDVG
310 320 330 340 350
WCGGLTTLVE IAAIAKARGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS
360 370 380 390 400
PDCATLRPQF DPILLGEPVP ERGRIHKSVL DKPGFGVELN RDCNLKRPYQ

H
Length:401
Mass (Da):44,202
Last modified:August 21, 2007 - v1
Checksum:iAFB4385C9AF18AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78069.1.
RefSeqiYP_001336299.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR78069; ABR78069; KPN_02652.
GeneIDi5341828.
KEGGikpn:KPN_02652.
PATRICi20459598. VBIKlePne13394_2673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR78069.1 .
RefSeqi YP_001336299.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TBU8.
SMRi A6TBU8. Positions 1-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_02652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR78069 ; ABR78069 ; KPN_02652 .
GeneIDi 5341828.
KEGGi kpn:KPN_02652.
PATRICi 20459598. VBIKlePne13394_2673.

Phylogenomic databases

eggNOGi COG4948.
HOGENOMi HOG000113755.
KOi K12661.
OMAi FCVELEA.
OrthoDBi EOG68Q0M0.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-2652-MONOMER.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_01288. Rhamnon_dehydrat.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiRHMD_KLEP7
AccessioniPrimary (citable) accession number: A6TBU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via a syn dehydration.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3