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A6TBU8

- RHMD_KLEP7

UniProt

A6TBU8 - RHMD_KLEP7

Protein

L-rhamnonate dehydratase

Gene

rhmD

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).UniRule annotation

    Catalytic activityi

    L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291SubstrateUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Metal bindingi222 – 2221MagnesiumUniRule annotation
    Metal bindingi248 – 2481MagnesiumUniRule annotation
    Metal bindingi276 – 2761MagnesiumUniRule annotation
    Sitei298 – 2981Increases basicity of active site HisUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation
    Sitei345 – 3451Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. L-rhamnonate dehydratase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular amino acid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-2652-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-rhamnonate dehydrataseUniRule annotation (EC:4.2.1.90UniRule annotation)
    Short name:
    RhamDUniRule annotation
    Gene namesi
    Name:rhmDUniRule annotation
    Ordered Locus Names:KPN78578_26080
    ORF Names:KPN_02652
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401L-rhamnonate dehydratasePRO_0000351700Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi272620.KPN_02652.

    Structurei

    3D structure databases

    ProteinModelPortaliA6TBU8.
    SMRiA6TBU8. Positions 1-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4948.
    HOGENOMiHOG000113755.
    KOiK12661.
    OMAiFCVELEA.
    OrthoDBiEOG68Q0M0.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPiMF_01288. Rhamnon_dehydrat.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR023444. L-Rhamnon_dehydrat.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEiPS00908. MR_MLE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6TBU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLPKIKHVR AWFIGGATAE QGAGGGDYHD QGANHWIDDH IATPMSKYKQ    50
    YEQSRQSFGI NVLGTLIVEV EADNGQTGFA VSTAGEMGCF IVEKHLNRFI 100
    EGKCVSDIKL IHDQMLNATL YYAGSGGLVM NTISCVDLAL WDLFGKVVGL 150
    PVYKLLGGAV RDEIQFYATG ARPDLAQEMG FIGGKMPTHW GPHDGDAGIR 200
    KDVAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PYNLKWIEEC 250
    LPPQQYEGYR ELKRQAPAGM MVTSGEHHGT LQSFRTLSET GIDIMQPDVG 300
    WCGGLTTLVE IAAIAKARGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS 350
    PDCATLRPQF DPILLGEPVP ERGRIHKSVL DKPGFGVELN RDCNLKRPYQ 400
    H 401
    Length:401
    Mass (Da):44,202
    Last modified:August 21, 2007 - v1
    Checksum:iAFB4385C9AF18AB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR78069.1.
    RefSeqiYP_001336299.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR78069; ABR78069; KPN_02652.
    GeneIDi5341828.
    KEGGikpn:KPN_02652.
    PATRICi20459598. VBIKlePne13394_2673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR78069.1 .
    RefSeqi YP_001336299.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6TBU8.
    SMRi A6TBU8. Positions 1-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_02652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR78069 ; ABR78069 ; KPN_02652 .
    GeneIDi 5341828.
    KEGGi kpn:KPN_02652.
    PATRICi 20459598. VBIKlePne13394_2673.

    Phylogenomic databases

    eggNOGi COG4948.
    HOGENOMi HOG000113755.
    KOi K12661.
    OMAi FCVELEA.
    OrthoDBi EOG68Q0M0.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-2652-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPi MF_01288. Rhamnon_dehydrat.
    InterProi IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR023444. L-Rhamnon_dehydrat.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEi PS00908. MR_MLE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiRHMD_KLEP7
    AccessioniPrimary (citable) accession number: A6TBU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Reaction proceeds via a syn dehydration.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3