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Reviewed, UniProtKB/Swiss-Prot A6TAC8 (MHPB_KLEP7)

Last modified March 2, 2010. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase

EC=1.13.11.16
Gene names
Name:mhpB
Ordered Locus Names:KPN78578_20880
ORF Names:KPN_02121
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
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Protein attributesHide

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively By similarity. HAMAP MF_01653

Catalytic activity

3-(2,3-dihydroxyphenyl)propanoate + O2 = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. HAMAP MF_01653

2,3-dihydroxicinnamic acid + O2 = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. HAMAP MF_01653

Cofactor

Fe2+ ion By similarity. HAMAP MF_01653

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01653

Subunit structure

Homotetramer By similarity. HAMAP MF_01653

Sequence similarities

Belongs to the ligB/mhpB extradiol dioxygenase family.

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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3143142,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase HAMAP MF_01653
PRO_0000337652

Sites

Active site1151Proton donor By similarity
Active site1791Proton acceptor By similarity
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SequencesHide

Sequence LengthMass (Da)Tools
A6TAC8-1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1B7069BDD1A9C77B

FASTA31434,404
        10         20         30         40         50         60 
MHAYLHCLSH TPLVGFVDPE QAVLDEVNRV IADARRRIAE FDPELVVLFA PDHYNGFFYD 

        70         80         90        100        110        120 
VMPPFCLGIG ATAIGDFASA AGDLPVPAEL AEACAHAILN SGIDLAVSYN MQVDHGFAQP 

       130        140        150        160        170        180 
LEFLLGGLDR VPVLPVFING VAAPLPGFQR TRLLGEAMGR FLNTLNKRVL ILGSGGLSHQ 

       190        200        210        220        230        240 
PPVPELAKAD AHLRDRLLGG GKQLPPDERE RRQQRVISAA RRFTEDPHSL HPLNPVWDNR 

       250        260        270        280        290        300 
FMSLLEQGRL SELDAIGNDE LSAMAGKSTH EIKTWVAAFA ALSAFGRWRS EGRYYRPIPE 

       310 
WIAGFGSLSA TTEI 

« Hide

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ReferencesHide

[1]McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR77549.1.
RefSeqYP_001335779.1.

3D structure databases

SMRA6TAC8. Positions 7-309.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6TAC8.

Genome annotation databases

GeneID5340517.
GenomeReviewsGene locus KPN78578_20880 in contig CP000647_GR.
KEGGkpn:KPN_02121.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG42398.
HOGENOMHBG565586.
OMAPLNPEWD.
ProtClustDBPRK13370.

Family and domain databases

HAMAPMF_01653. MhpB.
[Tree]
InterProIPR004183. Xdiol_dOase_3B.
[Graphical view]
PfamPF02900. LigB. 1 hit.
[Graphical view]
SUPFAMSSF53213. Xdiol_dOase_3B. 1 hit.
ProtoNetSearch...
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Entry informationHide

Entry nameMHPB_KLEP7
AccessionPrimary (citable) accession number: A6TAC8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: March 2, 2010
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents