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Protein

2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase

Gene

mhpC

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid.UniRule annotation

Catalytic activityi

(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + succinate.UniRule annotation
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate.UniRule annotation

Pathwayi: 3-phenylpropanoate degradation

This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 3-phenylpropanoate degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei192Catalytic role in ketonization of the dienol substrate (substrate destabilization)UniRule annotation1
Active sitei267Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciKPNE272620:G1G8J-2287-MONOMER
UniPathwayiUPA00714

Protein family/group databases

ESTHERiklep7-mhpc Carbon-carbon_bond_hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolaseUniRule annotation (EC:3.7.1.14UniRule annotation)
Alternative name(s):
2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolaseUniRule annotation
2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolaseUniRule annotation
2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolaseUniRule annotation
Gene namesi
Name:mhpCUniRule annotation
Ordered Locus Names:KPN78578_20870
ORF Names:KPN_02120
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003377831 – 2882-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolaseAdd BLAST288

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272620.KPN_02120

Structurei

3D structure databases

ProteinModelPortaliA6TAC7
SMRiA6TAC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MhpC family.Curated

Phylogenomic databases

eggNOGiENOG4107UB2 Bacteria
COG0596 LUCA
HOGENOMiHOG000028063
KOiK05714
OMAiCGHAAMM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01654 MhpC, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
IPR023791 MhpC_alpha/beta_hydrolase
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

A6TAC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQPQTEAA TSRFLNVDEG GRTLRIHIND CGDGKETVVM LHGSGPGATG
60 70 80 90 100
WANFSRNIDP LVEAGYRVLL LDCPGWGKSD AIVNSGSRSD LNARILKSVV
110 120 130 140 150
DQLGIDKVHL LGNLMGGHSA VAFTLSWPER VAKLVLMGGG TGGMSLFTPM
160 170 180 190 200
PTEGIKLLNA LYREPTIENL KKMMSIFVFD TRDLTEALFE ARLNNMLSRR
210 220 230 240 250
DHLDNFVKSL EANPKQFPDF GPRLGEISAP TLIVWGRNDR FVPMDAGLRL
260 270 280
LAGIAGSELH IYRDCGHWAQ WEHADSFNQL VLNFLARA
Length:288
Mass (Da):31,735
Last modified:August 21, 2007 - v1
Checksum:i1C358EB56BD36394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR77548.1
RefSeqiWP_015958582.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR77548; ABR77548; KPN_02120
KEGGikpn:KPN_02120

Entry informationi

Entry nameiMHPC_KLEP7
AccessioniPrimary (citable) accession number: A6TAC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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