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Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Pathwayi: 3-phenylpropanoate degradation

This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 3-phenylpropanoate degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Acyl-thioester intermediateUniRule annotation1
Binding sitei289NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi162 – 170NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00714

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:KPN78578_20850
ORF Names:KPN_02118
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003379821 – 316Acetaldehyde dehydrogenaseAdd BLAST316

Proteomic databases

PRIDEiA6TAC5

Interactioni

Subunit structurei

Interacts with MhpE.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_02118

Structurei

3D structure databases

ProteinModelPortaliA6TAC5
SMRiA6TAC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A6TAC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRL
60 70 80 90 100
GVATTHEGVG GLMQMAEFAD IDFVFDATSA GAHIKNDAAL REAKPGIRVI
110 120 130 140 150
DLTPAAIGPY CVPVVNLADN LHQGNVNMVT CGGQATIPMV AAVSRVAKVH
160 170 180 190 200
YAEIVASIAS QSAGPGTRAN IDEFTETTSQ AIEKVGGAGK GKAIIVLNPA
210 220 230 240 250
EPPLMMRDTV YILSELASQE AIAASIAEMA AAVQAYVPGY RLKQQVQFEV
260 270 280 290 300
IPEDRPVNLP GVGCFSGLKT AVYLEVEGAA HYLPAYAGNL DIMTSAALAT
310
AEQMAGAMHS AAGATA
Length:316
Mass (Da):32,915
Last modified:August 21, 2007 - v1
Checksum:i4CFED56175429DE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR77546.1
RefSeqiWP_014907417.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR77546; ABR77546; KPN_02118
KEGGikpn:KPN_02118

Similar proteinsi

Entry informationi

Entry nameiACDH_KLEP7
AccessioniPrimary (citable) accession number: A6TAC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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