Reviewed, UniProtKB/Swiss-Prot A6TAC5 (MHPF_KLEP7)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF
Ordered Locus Names:	KPN78578_20850
ORF Names:	KPN_02118

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A By similarity.
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01657
Subunit structure	Interacts with mhpE By similarity.
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000337982

Sequences

	Sequence		Length	Mass (Da)
	A6TAC5-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4CFED56175429DE3	FASTA	316	32,915
	10 20 30 40 50 60 MRKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRL GVATTHEGVG 70 80 90 100 110 120 GLMQMAEFAD IDFVFDATSA GAHIKNDAAL REAKPGIRVI DLTPAAIGPY CVPVVNLADN 130 140 150 160 170 180 LHQGNVNMVT CGGQATIPMV AAVSRVAKVH YAEIVASIAS QSAGPGTRAN IDEFTETTSQ 190 200 210 220 230 240 AIEKVGGAGK GKAIIVLNPA EPPLMMRDTV YILSELASQE AIAASIAEMA AAVQAYVPGY 250 260 270 280 290 300 RLKQQVQFEV IPEDRPVNLP GVGCFSGLKT AVYLEVEGAA HYLPAYAGNL DIMTSAALAT 310 AEQMAGAMHS AAGATA

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000647 Genomic DNA. Translation: ABR77546.1.
RefSeq	YP_001335776.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5338832.
GenomeReviews	Gene locus KPN78578_20850 in contig CP000647_GR.
KEGG	kpn:KPN_02118.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A6TAC5. HVKNDAF.
Family and domain databases
HAMAP	MF_01657. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MHPF_KLEP7

Accession

Primary (citable) accession number: A6TAC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 21, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)