Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6TAC4

- HOA_KLEP7

UniProt

A6TAC4 - HOA_KLEP7

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

4-hydroxy-2-oxovalerate aldolase

Gene

mhpE

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei14 – 141Transition state stabilizerUniRule annotation
Metal bindingi15 – 151ManganeseUniRule annotation
Active sitei18 – 181Proton acceptorUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Metal bindingi197 – 1971Manganese; via tele nitrogenUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Metal bindingi199 – 1991Manganese; via tele nitrogenUniRule annotation
Binding sitei288 – 2881SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-2-oxovalerate aldolase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2117-MONOMER.
UniPathwayiUPA00714.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxovalerate aldolaseUniRule annotation (EC:4.1.3.39UniRule annotation)
Short name:
HOAUniRule annotation
Alternative name(s):
4-hydroxy-2-keto-pentanoic acid aldolaseUniRule annotation
4-hydroxy-2-oxopentanoate aldolaseUniRule annotation
Gene namesi
Name:mhpEUniRule annotation
Ordered Locus Names:KPN78578_20840
ORF Names:KPN_02117
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3383384-hydroxy-2-oxovalerate aldolasePRO_0000337807Add
BLAST

Interactioni

Subunit structurei

Interacts with MhpF.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_02117.

Structurei

3D structure databases

ProteinModelPortaliA6TAC4.
SMRiA6TAC4. Positions 4-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 152Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the 4-hydroxy-2-oxovalerate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000048047.
KOiK01666.
OMAiHEPDMIY.
OrthoDBiEOG6C2WC0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01656. HOA.
InterProiIPR017629. 4OH_2_O-val_aldolase.
IPR013785. Aldolase_TIM.
IPR012425. DmpG_comm.
IPR000891. PYR_CT.
[Graphical view]
PANTHERiPTHR10277:SF3. PTHR10277:SF3. 1 hit.
PfamiPF07836. DmpG_comm. 1 hit.
PF00682. HMGL-like. 1 hit.
[Graphical view]
ProDomiPD005364. DmpG_comm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITEiPS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TAC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGKKLYISD VTLRDGMHAI RHQYSLAQVQ QIAGALDKAG VDSIEVAHGD
60 70 80 90 100
GLQGSSFNYG FGAHSDIAWI EAAAAAVSQA KIATLLLPGI GTLHDLKAAY
110 120 130 140 150
QAGARVVRVA THCSEADVAA QHIAFARELG MDTVGFLMMS HMISPQALAQ
160 170 180 190 200
QALKMESYGA TCIYVVDSGG AMNMNDIRDR FRALKAVLKP ETATGMHAHH
210 220 230 240 250
NLSLGVANSI VAVEEGCDRI DASLAGMGAG AGNAPLEVFI AAADKLGWQH
260 270 280 290 300
GTDLYALMNA ADELVRPLQD RPVRVDRETL ALGYAGVYSS FLRHSEAAAK
310 320 330
RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLLNRNK
Length:338
Mass (Da):35,981
Last modified:August 21, 2007 - v1
Checksum:iFEB2817892AB3A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR77545.1.
RefSeqiYP_001335775.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR77545; ABR77545; KPN_02117.
GeneIDi5338831.
KEGGikpn:KPN_02117.
PATRICi20458522. VBIKlePne13394_2146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR77545.1 .
RefSeqi YP_001335775.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TAC4.
SMRi A6TAC4. Positions 4-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_02117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR77545 ; ABR77545 ; KPN_02117 .
GeneIDi 5338831.
KEGGi kpn:KPN_02117.
PATRICi 20458522. VBIKlePne13394_2146.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000048047.
KOi K01666.
OMAi HEPDMIY.
OrthoDBi EOG6C2WC0.

Enzyme and pathway databases

UniPathwayi UPA00714 .
BioCyci KPNE272620:GKDC-2117-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01656. HOA.
InterProi IPR017629. 4OH_2_O-val_aldolase.
IPR013785. Aldolase_TIM.
IPR012425. DmpG_comm.
IPR000891. PYR_CT.
[Graphical view ]
PANTHERi PTHR10277:SF3. PTHR10277:SF3. 1 hit.
Pfami PF07836. DmpG_comm. 1 hit.
PF00682. HMGL-like. 1 hit.
[Graphical view ]
ProDomi PD005364. DmpG_comm. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITEi PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiHOA_KLEP7
AccessioniPrimary (citable) accession number: A6TAC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3