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A6TAC4

- HOA_KLEP7

UniProt

A6TAC4 - HOA_KLEP7

Protein

4-hydroxy-2-oxovalerate aldolase

Gene

mhpE

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei14 – 141Transition state stabilizerUniRule annotation
    Metal bindingi15 – 151ManganeseUniRule annotation
    Active sitei18 – 181Proton acceptorUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Metal bindingi197 – 1971Manganese; via tele nitrogenUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation
    Metal bindingi199 – 1991Manganese; via tele nitrogenUniRule annotation
    Binding sitei288 – 2881SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-2-oxovalerate aldolase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-2117-MONOMER.
    UniPathwayiUPA00714.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxovalerate aldolaseUniRule annotation (EC:4.1.3.39UniRule annotation)
    Short name:
    HOAUniRule annotation
    Alternative name(s):
    4-hydroxy-2-keto-pentanoic acid aldolaseUniRule annotation
    4-hydroxy-2-oxopentanoate aldolaseUniRule annotation
    Gene namesi
    Name:mhpEUniRule annotation
    Ordered Locus Names:KPN78578_20840
    ORF Names:KPN_02117
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3383384-hydroxy-2-oxovalerate aldolasePRO_0000337807Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with MhpF.UniRule annotation

    Protein-protein interaction databases

    STRINGi272620.KPN_02117.

    Structurei

    3D structure databases

    ProteinModelPortaliA6TAC4.
    SMRiA6TAC4. Positions 4-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 152Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the 4-hydroxy-2-oxovalerate aldolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    HOGENOMiHOG000048047.
    KOiK01666.
    OMAiHEPDMIY.
    OrthoDBiEOG6C2WC0.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01656. HOA.
    InterProiIPR017629. 4OH_2_O-val_aldolase.
    IPR013785. Aldolase_TIM.
    IPR012425. DmpG_comm.
    IPR000891. PYR_CT.
    [Graphical view]
    PANTHERiPTHR10277:SF3. PTHR10277:SF3. 1 hit.
    PfamiPF07836. DmpG_comm. 1 hit.
    PF00682. HMGL-like. 1 hit.
    [Graphical view]
    ProDomiPD005364. DmpG_comm. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR03217. 4OH_2_O_val_ald. 1 hit.
    PROSITEiPS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6TAC4-1 [UniParc]FASTAAdd to Basket

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    MNGKKLYISD VTLRDGMHAI RHQYSLAQVQ QIAGALDKAG VDSIEVAHGD    50
    GLQGSSFNYG FGAHSDIAWI EAAAAAVSQA KIATLLLPGI GTLHDLKAAY 100
    QAGARVVRVA THCSEADVAA QHIAFARELG MDTVGFLMMS HMISPQALAQ 150
    QALKMESYGA TCIYVVDSGG AMNMNDIRDR FRALKAVLKP ETATGMHAHH 200
    NLSLGVANSI VAVEEGCDRI DASLAGMGAG AGNAPLEVFI AAADKLGWQH 250
    GTDLYALMNA ADELVRPLQD RPVRVDRETL ALGYAGVYSS FLRHSEAAAK 300
    RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLLNRNK 338
    Length:338
    Mass (Da):35,981
    Last modified:August 21, 2007 - v1
    Checksum:iFEB2817892AB3A03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR77545.1.
    RefSeqiYP_001335775.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR77545; ABR77545; KPN_02117.
    GeneIDi5338831.
    KEGGikpn:KPN_02117.
    PATRICi20458522. VBIKlePne13394_2146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR77545.1 .
    RefSeqi YP_001335775.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6TAC4.
    SMRi A6TAC4. Positions 4-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_02117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR77545 ; ABR77545 ; KPN_02117 .
    GeneIDi 5338831.
    KEGGi kpn:KPN_02117.
    PATRICi 20458522. VBIKlePne13394_2146.

    Phylogenomic databases

    eggNOGi COG0119.
    HOGENOMi HOG000048047.
    KOi K01666.
    OMAi HEPDMIY.
    OrthoDBi EOG6C2WC0.

    Enzyme and pathway databases

    UniPathwayi UPA00714 .
    BioCyci KPNE272620:GKDC-2117-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01656. HOA.
    InterProi IPR017629. 4OH_2_O-val_aldolase.
    IPR013785. Aldolase_TIM.
    IPR012425. DmpG_comm.
    IPR000891. PYR_CT.
    [Graphical view ]
    PANTHERi PTHR10277:SF3. PTHR10277:SF3. 1 hit.
    Pfami PF07836. DmpG_comm. 1 hit.
    PF00682. HMGL-like. 1 hit.
    [Graphical view ]
    ProDomi PD005364. DmpG_comm. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR03217. 4OH_2_O_val_ald. 1 hit.
    PROSITEi PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiHOA_KLEP7
    AccessioniPrimary (citable) accession number: A6TAC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3