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A6TAC4

- HOA_KLEP7

UniProt

A6TAC4 - HOA_KLEP7

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Protein

4-hydroxy-2-oxovalerate aldolase

Gene
mhpE, KPN78578_20840, KPN_02117
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei14 – 141Transition state stabilizer By similarity
Metal bindingi15 – 151Manganese By similarity
Active sitei18 – 181Proton acceptor Reviewed prediction
Binding sitei168 – 1681Substrate By similarity
Metal bindingi197 – 1971Manganese; via tele nitrogen By similarity
Binding sitei197 – 1971Substrate By similarity
Metal bindingi199 – 1991Manganese; via tele nitrogen By similarity
Binding sitei288 – 2881Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxovalerate aldolase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 3-phenylpropionate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2117-MONOMER.
UniPathwayiUPA00714.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxovalerate aldolase (EC:4.1.3.39)
Short name:
HOA
Alternative name(s):
4-hydroxy-2-keto-pentanoic acid aldolase
4-hydroxy-2-oxopentanoate aldolase
Gene namesi
Name:mhpE
Ordered Locus Names:KPN78578_20840
ORF Names:KPN_02117
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3383384-hydroxy-2-oxovalerate aldolaseUniRule annotationPRO_0000337807Add
BLAST

Interactioni

Subunit structurei

Interacts with MhpF By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_02117.

Structurei

3D structure databases

ProteinModelPortaliA6TAC4.
SMRiA6TAC4. Positions 4-338.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 152Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000048047.
KOiK01666.
OMAiHEPDMIY.
OrthoDBiEOG6C2WC0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01656. HOA.
InterProiIPR017629. 4OH_2_O-val_aldolase.
IPR013785. Aldolase_TIM.
IPR012425. DmpG_comm.
IPR000891. PYR_CT.
[Graphical view]
PANTHERiPTHR10277:SF3. PTHR10277:SF3. 1 hit.
PfamiPF07836. DmpG_comm. 1 hit.
PF00682. HMGL-like. 1 hit.
[Graphical view]
ProDomiPD005364. DmpG_comm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITEiPS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TAC4-1 [UniParc]FASTAAdd to Basket

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MNGKKLYISD VTLRDGMHAI RHQYSLAQVQ QIAGALDKAG VDSIEVAHGD    50
GLQGSSFNYG FGAHSDIAWI EAAAAAVSQA KIATLLLPGI GTLHDLKAAY 100
QAGARVVRVA THCSEADVAA QHIAFARELG MDTVGFLMMS HMISPQALAQ 150
QALKMESYGA TCIYVVDSGG AMNMNDIRDR FRALKAVLKP ETATGMHAHH 200
NLSLGVANSI VAVEEGCDRI DASLAGMGAG AGNAPLEVFI AAADKLGWQH 250
GTDLYALMNA ADELVRPLQD RPVRVDRETL ALGYAGVYSS FLRHSEAAAK 300
RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLLNRNK 338
Length:338
Mass (Da):35,981
Last modified:August 21, 2007 - v1
Checksum:iFEB2817892AB3A03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77545.1.
RefSeqiYP_001335775.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR77545; ABR77545; KPN_02117.
GeneIDi5338831.
KEGGikpn:KPN_02117.
PATRICi20458522. VBIKlePne13394_2146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77545.1 .
RefSeqi YP_001335775.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6TAC4.
SMRi A6TAC4. Positions 4-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_02117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR77545 ; ABR77545 ; KPN_02117 .
GeneIDi 5338831.
KEGGi kpn:KPN_02117.
PATRICi 20458522. VBIKlePne13394_2146.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000048047.
KOi K01666.
OMAi HEPDMIY.
OrthoDBi EOG6C2WC0.

Enzyme and pathway databases

UniPathwayi UPA00714 .
BioCyci KPNE272620:GKDC-2117-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01656. HOA.
InterProi IPR017629. 4OH_2_O-val_aldolase.
IPR013785. Aldolase_TIM.
IPR012425. DmpG_comm.
IPR000891. PYR_CT.
[Graphical view ]
PANTHERi PTHR10277:SF3. PTHR10277:SF3. 1 hit.
Pfami PF07836. DmpG_comm. 1 hit.
PF00682. HMGL-like. 1 hit.
[Graphical view ]
ProDomi PD005364. DmpG_comm. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITEi PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiHOA_KLEP7
AccessioniPrimary (citable) accession number: A6TAC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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