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A6TA11 (MDTK_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene names
Name:mdtK
Ordered Locus Names:KPN78578_19710
ORF Names:KPN_02001
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity. HAMAP-Rule MF_00400

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00400.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

drug transmembrane transporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Multidrug resistance protein MdtK HAMAP-Rule MF_00400
PRO_1000049614

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane276 – 29621Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane418 – 43821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6TA11 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1EA07371744ADA82

FASTA45749,641
        10         20         30         40         50         60 
MQKYFVEARQ LLALAIPVIL AQVAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF 

        70         80         90        100        110        120 
GHGLLLALTP VVAQLNGSGR RERIAPQVRQ GFWLAGFVSV LIMVVLWNAG YIISSMHNID 

       130        140        150        160        170        180 
PLLAEKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY 

       190        200        210        220        230        240 
GHFGMPELGG VGCGVATASV YWVMFASMLW WVRRARTMRD IRCAERFSGP DFAVLLRLVQ 

       250        260        270        280        290        300 
LGLPIALALF FEVTLFAVVA LLVSPLGIID VAGHQIALNF SSLMFVLPLS LAAAVTIRVG 

       310        320        330        340        350        360 
FRLGQGSTID AQVSARTGVG VGVCLAVFTA IFTVLMRKQI ALLYNDNPEV VTLASHLMLL 

       370        380        390        400        410        420 
AAIYQISDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL PSGYLLALTD MIVPRMGPAG 

       430        440        450 
FWCGFIIGLT SAAIMMMLRM RFLQRQPSSI ILQRAAR 

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR77432.1.
RefSeqYP_001335662.1. NC_009648.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272620.KPN_02001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR77432; ABR77432; KPN_02001.
GeneID5339770.
KEGGkpn:KPN_02001.
PATRIC20458290. VBIKlePne13394_2033.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000038538.
KOK03327.
OMAGGVGCGW.
OrthoDBEOG6423C5.

Enzyme and pathway databases

BioCycKPNE272620:GKDC-2001-MONOMER.

Family and domain databases

HAMAPMF_00400. MdtK.
InterProIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDTK_KLEP7
AccessionPrimary (citable) accession number: A6TA11
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families