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A6TA11

- MDTK_KLEP7

UniProt

A6TA11 - MDTK_KLEP7

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Protein

Multidrug resistance protein MdtK

Gene
mdtK, KPN78578_19710, KPN_02001
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-2001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene namesi
Name:mdtK
Ordered Locus Names:KPN78578_19710
ORF Names:KPN_02001
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Transmembranei53 – 7321Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei276 – 29621Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei357 – 37721Helical; Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Transmembranei418 – 43821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKUniRule annotationPRO_1000049614Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_02001.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiGGVGCGW.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6TA11-1 [UniParc]FASTAAdd to Basket

« Hide

MQKYFVEARQ LLALAIPVIL AQVAQTAMGF VDTVMAGGYS ATDMAAVAIG    50
TSIWLPAILF GHGLLLALTP VVAQLNGSGR RERIAPQVRQ GFWLAGFVSV 100
LIMVVLWNAG YIISSMHNID PLLAEKAVGY LRALLWGAPG YLFFQVARNQ 150
CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATASV 200
YWVMFASMLW WVRRARTMRD IRCAERFSGP DFAVLLRLVQ LGLPIALALF 250
FEVTLFAVVA LLVSPLGIID VAGHQIALNF SSLMFVLPLS LAAAVTIRVG 300
FRLGQGSTID AQVSARTGVG VGVCLAVFTA IFTVLMRKQI ALLYNDNPEV 350
VTLASHLMLL AAIYQISDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL 400
PSGYLLALTD MIVPRMGPAG FWCGFIIGLT SAAIMMMLRM RFLQRQPSSI 450
ILQRAAR 457
Length:457
Mass (Da):49,641
Last modified:August 21, 2007 - v1
Checksum:i1EA07371744ADA82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77432.1.
RefSeqiYP_001335662.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR77432; ABR77432; KPN_02001.
GeneIDi5339770.
KEGGikpn:KPN_02001.
PATRICi20458290. VBIKlePne13394_2033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77432.1 .
RefSeqi YP_001335662.1. NC_009648.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_02001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR77432 ; ABR77432 ; KPN_02001 .
GeneIDi 5339770.
KEGGi kpn:KPN_02001.
PATRICi 20458290. VBIKlePne13394_2033.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000038538.
KOi K03327.
OMAi GGVGCGW.
OrthoDBi EOG6423C5.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-2001-MONOMER.

Family and domain databases

HAMAPi MF_00400. MdtK.
InterProi IPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiMDTK_KLEP7
AccessioniPrimary (citable) accession number: A6TA11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi