Reviewed, UniProtKB/Swiss-Prot A6T9W8 (ADD_KLEP7)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	KPN78578_19280
ORF Names:	KPN_01958

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Adenosine deaminase HAMAP MF_00540		PRO_1000017664
Sites
	Active site	197	1	Potential
	Active site	245	1	Potential
	Active site	278	1	Potential
	Active site	279	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A6T9W8-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 1A6A7B30C4F65237	FASTA	333	36,230
	10 20 30 40 50 60 MIDSSLPLTD IHRHLDGNIR AQTILDLGRE FNIALPATTL DTLRPHVQVT SLEPDLVSFL 70 80 90 100 110 120 AKLDWGVKVL ASLEACRRVA YENVEDAARN GLHYVELRFS PRYMAMTHRL PVDGVVEAVI 130 140 150 160 170 180 AGVQEGCRDF QVDARLIGIL SRTFGEAACQ EELAALLAHR EGITALDLAG DELGFPGTLF 190 200 210 220 230 240 RNHFNQARDA GWHITVHAGE AAGPESIWQA IRELGAERIG HGVKAVEDPA LMDYLAEHRI 250 260 270 280 290 300 GIESCLTSNV QTSTVASLAQ HPLKQFLEHG VLASLNTDDP AVQGVDIIHE YTVAAPAAGL 310 320 330 SREQIRQAQI NGLTLAFLGE QEKAALIQRV AKG

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR77389.1.
RefSeq	YP_001335619.1.
3D structure databases
SMR	A6T9W8. Positions 5-332.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T9W8.
Genome annotation databases
GeneID	5341206.
GenomeReviews	Gene locus KPN78578_19280 in contig CP000647_GR.
KEGG	kpn:KPN_01958.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	FLKKLDW.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_KLEP7

Accession

Primary (citable) accession number: A6T9W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)