A6T9W8 (ADD_KLEP7) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 30.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenosine deaminase EC=3.5.4.4 Alternative name(s): Adenosine aminohydrolase | ||||||
| Gene names |
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| Organism | Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 272620 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella |
Protein attributes
| Sequence length | 333 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Adenosine + H2O = inosine + NH3. HAMAP MF_00540 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | adenosine deaminase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 333 | 333 | Adenosine deaminase HAMAP MF_00540 | PRO_1000017664 | |||||
Sites | |||||||||
| Active site | 200 | 1 | Proton donor By similarity | ||||||
| Metal binding | 12 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 14 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 197 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 278 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 14 | 1 | Substrate By similarity | ||||||
| Binding site | 16 | 1 | Substrate By similarity | ||||||
| Binding site | 170 | 1 | Substrate; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Binding site | 279 | 1 | Substrate By similarity | ||||||
| Site | 221 | 1 | Important for catalytic activity By similarity | ||||||
Sequences
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References
| [1] | The Klebsiella pneumonia Genome Sequencing Project McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700721 / MGH 78578. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000647 Genomic DNA. Translation: ABR77389.1. |
| RefSeq | YP_001335619.1. NC_009648.1. |
3D structure databases | |
| ProteinModelPortal | A6T9W8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A6T9W8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5341206. |
| GenomeReviews | Gene locus KPN78578_19280 in contig CP000647_GR. |
| KEGG | kpn:KPN_01958. |
| PATRIC | 20458204. VBIKlePne13394_1990. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1816. |
| HOGENOM | HBG630382. |
| OMA | PYYMAMN. |
| ProtClustDB | CLSK2400760. |
Family and domain databases | |
| HAMAP | MF_00540. A_deaminase. [Tree] |
| InterPro | IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view] |
| KO | K01488. |
| PANTHER | PTHR11409:SF21. PTHR11409:SF21. 1 hit. |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01430. Aden_deam. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADD_KLEP7 | ||||||||
| Accession | Primary (citable) accession number: A6T9W8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with