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A6T9T4 (A6T9T4_KLEP7) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-aminobutyraldehyde dehydrogenase HAMAP MF_01275
EC=1.2.1.19 HAMAP MF_01275
Alternative name(s):
1-pyrroline dehydrogenase HAMAP MF_01275
4-aminobutanal dehydrogenase HAMAP MF_01275
Gene names
Name:ydcW EMBL ABR77355.1
Synonyms:prr HAMAP MF_01275
Ordered Locus Names:KPN78578_18940
ORF Names:KPN_01924 EMBL ABR77355.1
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) By similarity. HAMAP MF_01275

Catalytic activity

4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH. HAMAP MF_01275

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1. HAMAP MF_01275

Subunit structure

Homotetramer By similarity. HAMAP MF_01275

Miscellaneous

4-aminobutanal is also called gamma-aminobutyraldehyde By similarity. HAMAP MF_01275

Sequence similarities

Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily. HAMAP MF_01275

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding178 – 1814NAD By similarity HAMAP MF_01275
Nucleotide binding231 – 2377NAD By similarity HAMAP MF_01275

Sites

Active site2521 By similarity HAMAP MF_01275
Active site2861Nucleophile By similarity HAMAP MF_01275
Binding site1521NAD; via carbonyl oxygen By similarity HAMAP MF_01275
Binding site2151NAD By similarity HAMAP MF_01275

Sequences

Sequence LengthMass (Da)Tools
A6T9T4 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 586745300FDB6740

FASTA48151,214
        10         20         30         40         50         60 
MKQDNAMQHN LLINGKLVAG EGEKVPVYNP ATGEVILEIA EATAAQVDAA VEAADRAFDA 

        70         80         90        100        110        120 
WSQTTPKTRA ECLLKLADAI SAQAETLAQL ESLNCGKPLH CVINDEMPAI VDVFRFFAGA 

       130        140        150        160        170        180 
ARCLPGMAAG EYLEGHTSMI RRDPVGVVAS IAPWNYPLMM AAWKLAPALA AGNCVVIKPS 

       190        200        210        220        230        240 
EITPLTALKL AELAKDIFPE GVINVLFGRG KTVGDPLTAH VKVRMVSLTG SIATGAHIIG 

       250        260        270        280        290        300 
HTASSIKRTH MELGGKAPVI VFDDADIDAV VDGVRTFGFY NAGQDCTAAC RIYAQQGIYD 

       310        320        330        340        350        360 
QLVEKLGAAV ASLKMGAPED AATELGPLSS LAHLERVSAA VEAARALPHI KVVTGGSRAD 

       370        380        390        400        410        420 
GAGYYFQPTL LAGARQEDAI VQREVFGPVV SVTPFSDEAQ ALSWANDSQY GLASSVWTKD 

       430        440        450        460        470        480 
VGRAHRLSAR LQYGCTWVNT HFMLVSEMPH GGQKLSGYGK DMSMYGLEDY TVVRHVMVKH 


S

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References

[1]McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000647 Genomic DNA. Translation: ABR77355.1.
RefSeqYP_001335585.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6T9T4.
SMRA6T9T4. Positions 7-480.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6T9T4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5341796.
GenomeReviewsGene locus KPN78578_18940 in contig CP000647_GR.
KEGGkpn:KPN_01924.
PATRIC20458130. VBIKlePne13394_1953.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMACRIYAQQ.
ProtClustDBPRK13473.

Family and domain databases

HAMAPMF_01275. Aldedh_Prr.
[Tree]
InterProIPR017749. 1-pyrroline_dehydrogenase.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00137.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03374. ABALDH. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6T9T4_KLEP7
AccessionPrimary (citable) accession number: A6T9T4
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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