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Protein

Catalase-peroxidase

Gene

katG

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Transition state stabilizerUniRule annotation
Active sitei106 – 1061Proton acceptorUniRule annotation
Metal bindingi267 – 2671Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-1819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:KPN78578_17890
ORF Names:KPN_01819
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020UniRule annotationAdd
BLAST
Chaini21 – 725705Catalase-peroxidasePRO_0000354814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki105 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-105)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA6T9H9.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_01819.

Structurei

3D structure databases

ProteinModelPortaliA6T9H9.
SMRiA6T9H9. Positions 28-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6T9H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSNDPSNN ASAGKCPFHA ETPKQSAGSG TANRDWWPNQ LRVDLLNQHS
60 70 80 90 100
NRSNPLGENF NYREEFKKLD YSALKADLRA LLTDSQEWWP ADWGSYIGLF
110 120 130 140 150
IRMAWHGAGT YRTVDGRGGA GRGQQRFAPL NSWPDNVSLD KARRLLWPVK
160 170 180 190 200
QKYGQKISWA DLYMLAGNVA LENAGFRTFG FGAGREDVWE PDLDVDWGDE
210 220 230 240 250
KEWLAHRHPE SLAKQAIGAT EMGLIYVNPE GPNASGEPLS AAAAIRATFG
260 270 280 290 300
NMAMDDEEIV ALIAGGHTLG KTHGAAETSH VGAEPEAAPL EAQGLGWHSS
310 320 330 340 350
YGSGAGADAI TSGLEVVWTQ TPTQWSNYFF ENLFKYEWVQ TRSPAGAIQF
360 370 380 390 400
EAKDAPEIIP DPFNPEKKRK PTMLVTDLTL RFDPEFEKIS RRFLNDPQAF
410 420 430 440 450
NEAFARAWFK LTHRDMGPKS RYLGPEVPKE DLIWQDPLPA ATHQPSAEDI
460 470 480 490 500
ASLKTAIAGA GLSVSELVSV AWASASTFRG GDKRGGANGA RLALAPQKDW
510 520 530 540 550
PVNAIASRVL PTLQAIQRAS GKASLADIIV LAGVVGVEQA AAAAGVSVNV
560 570 580 590 600
PFTPGRVDAL PEQTDVESFD LLQPLADGFR NYRRIEGGVS TETLLIDKAQ
610 620 630 640 650
QLTLTAPEMT VLVGGLRVLG ANYDGSKHGV FTDRVGVLSN DFFVNLLDMA
660 670 680 690 700
TVWKAADDNA ELFTGSDRKT GEAKYSATRV DLVFGSNSVL RALAEVYACA
710 720
DGQQKLVHDF VAAWTKVMNL DRFDL
Length:725
Mass (Da):78,966
Last modified:August 21, 2007 - v1
Checksum:i1BA0136F73C20E24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR77250.1.
RefSeqiWP_004176050.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR77250; ABR77250; KPN_01819.
KEGGikpn:KPN_01819.
PATRICi20457922. VBIKlePne13394_1849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR77250.1.
RefSeqiWP_004176050.1. NC_009648.1.

3D structure databases

ProteinModelPortaliA6T9H9.
SMRiA6T9H9. Positions 28-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_01819.

Proteomic databases

PRIDEiA6T9H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR77250; ABR77250; KPN_01819.
KEGGikpn:KPN_01819.
PATRICi20457922. VBIKlePne13394_1849.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-1819-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_KLEP7
AccessioniPrimary (citable) accession number: A6T9H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.